This is a 27-year-old male, 1 year ago, no cause of yellow rotten stool, 2-3 times / day, intermittent blood dripping, outside the hospital colonoscopy suggests: ulcerative colitis; to take lurasulfapyridine, metharazine, no improvement. 5 months ago appeared diarrhea, 7-8 times / day, yellow watery, with a small amount of mucus blood stool, Shenzhen Hospital of Traditional Chinese Medicine hospital, check Hb 62g / l, to symptomatic treatment without improvement, 4 months ago Appeared obvious bloody stool, 7-8 times / day, nighttime defecation mainly, with lower abdominal pain; and the right side of the limb weakness, inability to move, external hospital head MR suggests: left temporoparietal junctional area mass, astrocytoma may (later confirmed to be brain hemorrhage), this is the patient external hospital colonoscopy, the ulcer of the intestine bleeding very serious. Later, the external hospital also tried class gram, hormone and mesalachin treatment, but unfortunately all the treatments did not help, but the diarrhea became more and more severe! The patient had been suffering for more than 2 whole months, and when he was transferred to me, he was already in a state of cachexia. The 180 cm young man only weighed 33 kg and was already unable to stand up in bed and was extremely weak. This is the condition when he was just admitted to the hospital, he can be described as thin and bony. Above is the patient’s intestinal CTE and colonoscopy, we can see that the lesion of colon is very serious after admission, the whole intestine is full of ulcers and bleeding, from the CT view of the colon is lead tube-like ankylosis, is a typical patient with severe UC intestinal manifestations. After this patient was admitted to the hospital, we first adjusted the patient’s nutritional status through parenteral and enteral nutrition, followed by various drug regimens to preserve the patient’s colon through cyclosporine, thalidomide, adalimumab, tacrolimus, mesalachine oral + enema, hormone oral + enema. Things are often not so perfect, and the rate of patients with severe UC requiring surgical removal of the colon is high when they respond very poorly to conventional therapy. The patient recovered very well after the surgery, although the stoma was left in place, the patient was able to carry out normal life, the blood in the stool disappeared, and the weight was restored to more than 20 pounds. Now that more than six months have passed since the surgery, we have reviewed the patient’s colonoscopy and now the intestine is basically free of lesions and ready to close the stoma and let him live a normal life! Through this case, I hope all ulcerated patients will not lose their confidence under any circumstances, as long as they have confidence, they can overcome any hardship and any predicament, go!