Uterine fibroids are the most common benign tumors of the female reproductive system and the most common tumors of the human body, mostly seen in women aged 30-50. A few of these fibroids can become malignant, i.e., sarcomatous, and domestic statistics show that the incidence is 0.4%-0.8%, mostly in older women. Patients with uterine fibroids who have been examined by a gynecologist and have no indication for surgery for the time being need to be followed up closely and regularly. During the follow-up, the following signs may indicate that the fibroids are at risk of malignancy: rapid increase of fibroids within a short period of time or irregular vaginal bleeding, a lump may be found in the abdomen, and if the enlarged fibroids compress the surrounding tissues, symptoms such as frequent urination, difficulty in urination, urinary retention or difficulty in defecation may occur. In particular, postmenopausal women with fibroids that do not shrink but increase in size should be alerted to the malignant transformation of fibroids. Once malignant fibroids reach the middle and late stages, they will show malignant manifestations, such as weight loss, weakness and pain. Although uterine fibroids are a common benign tumor, there is also a risk of malignancy, so it is important to pay sufficient attention to women, and regular examination of fibroids according to medical advice, and timely surgery to remove them once signs of malignancy appear, is an effective way to prevent such diseases.