There are two options for hyperthyroidism medication, one is to apply anti-hyperthyroidism medication alone, monotherapy (tabazol or prothi), and the second is anti-hyperthyroidism medication plus eugenol, which is called block and replace therapy or combination therapy in foreign countries. It depends on the doctor’s custom. In terms of advantages and disadvantages, the first method has the advantage of less use of antihyperthyroid drugs. The second method has the advantage of avoiding hypothyroidism, and the time between tests may be longer. In addition, the hybrid method should be preferred for patients with hyperthyroidism with proptosis because it can reduce the fluctuation of hormone levels. However, the disadvantage of the mixed method is that the antihyperthyroid drugs have to be administered more frequently, which may cause more side effects. As for when to add eugenol, how to add it and what are the indicators, it is not clear in a sentence or two.