Lower extremity atherosclerosis-occlusive disease (ASO) is a serious arterial disease commonly seen in vasculitis, which is a local manifestation of systemic atherosclerosis in the extremities and is a degenerative, proliferative change in the intima and middle layers of the systemic arteries, causing the vessel walls to harden, shrink, and lose elasticity, resulting in secondary thrombosis, leading to progressive reduction or interruption of distal blood flow. The disease is most common in the lower extremities and is most common in middle-aged and older men over 45 years of age, with a progressive increase in incidence. Hypertension, diabetes mellitus, smoking and hyperlipidemia are the four major risk factors. Clinical manifestations: It is more common in the lower extremities. Due to impaired blood supply, the lower limbs become cold, numb and intermittent claudication, i.e., numbness, pain and even spasm of the gastrocnemius muscle occurs when walking, which disappears after rest and reappears when walking again; in severe cases, there may be persistent pain, and the arteries of the lower limbs, especially the dorsalis pedis artery, are weakened or disappear. Severe arterial occlusion may lead to foot ulceration and necrosis. Etiology: The causes and mechanisms of this disease are not fully understood. Hyperlipidemia, hypertension, smoking, diabetes, obesity, heritage, excessive stress (work, life stress), age (male > 45 years old, female > 55 years old), irregular life, etc., are all risk factors. Prevention: 1. Diet: excessive cholesterol-rich foods such as beef (pig) brain, egg yolk, eel, liver, cuttlefish, etc. should be avoided. To supplement protein can eat low-cholesterol foods such as: pork (beef) lean meat, chicken (duck) meat, egg whites, milk, etc.. Peanut oil and coconut oil should also be avoided because they can both promote the formation of atherosclerosis. And limit sugar diet, eat more vitamin-rich foods such as vegetables, fruits and protein-rich foods such as lean meat, beans and soy products. Avoid eating spicy and stimulating food, no alcohol, no chili, no mutton or dog meat. 2, physical activity: to participate in certain physical activity to prevent obesity, exercise the function of the circulatory system and adjust the lipid metabolism are beneficial, is an active measure to prevent the disease. 3, reasonable arrangement of life: should pay attention to the combination of work and rest, try to avoid emotional excitement, life should be regular, keep a happy mood. 4, other: abstain from alcohol; prevent trauma; prevent cold and keep warm: patients suffering from atherosclerosis occlusive disease should wear cotton clothes one season earlier than normal, and wear comfortable and loose shoes, not squeeze the foot shoes.