Chest pain as a common symptom may be mild, but it may also be a manifestation of myocardial infarction. What is the risk of myocardial infarction and death within 30 days if a patient with chest pain has a negative test for high-sensitivity troponin T (hs-cTnT) (<5 ng/l) and no ischemic changes on the electrocardiogram (ECG)? A study by Bandstein N. et al. from Sweden concluded that the risk of myocardial infarction and death within 30 days in patients with chest pain with an initial hs-cTnT <5 ng/l and no ischemic changes in ECG is very low and that such patients can be safely discharged from the hospital. The study collected 14,636 patients with chest pain from Karolinska University Hospital over a 2-year period, all of whom were tested at least once for hs-cTnT. 8907 patients (61%) had initial hs-cTnT <5 ng/l, 21% had 5 -14 ng/l, and 18% had hs-cTnT >14 ng/l. At 30 days of follow-up, a total of 39 (0.44%) hs-cTnT-negative patients had myocardial infarction, and 15 (0.17%) of them had no ECG ischemic changes. The calculated results showed that hs-cTnT-negative and ECG without ischemic changes had a negative predictive value of 99.8% (95% CI: 99.7-99.9) for myocardial infarction within 30 days and a negative predictive value of 100% for death. (Li Jun Abstract) Li Jun, Department of Cardiovascular Medicine, Guang’anmen Hospital, Chinese Academy of Traditional Chinese Medicine J Am Coll Cardiol. 2014, 63:2569-2578.