At present, there is no evidence to prove that the big three suns is more serious than the small three suns and more likely to be transformed into cancer. It is necessary to combine other laboratory indicators and clinical symptoms to make a judgment. It is possible that the infectiousness of triple III is higher than that of triple III, but the condition is not necessarily more serious, which needs to be judged by the combination of liver function, liver ultrasound, alpha-fetoprotein, liver fibrosis, and liver hardness indicators. Minor triple positive may also have heavy hepatitis, cirrhosis or combined liver cancer, the condition will be more serious, while patients with major triple positive may also be in the state of long-term viral carriage, and will not cause more serious liver function damage. Therefore, there is no such thing as major triple positive is more serious than minor triple positive, and it is easy to be transformed into liver cancer.