Urine microalbumin 220mg/24h is stage II of diabetic nephropathy. Diabetes mellitus presenting with chronic renal lesions, i.e. diabetic nephropathy, can be categorized into five stages according to the severity of the occurrence and development of renal damage. Stage I: no nephropathy manifestations, elevated GFR, glomerular and tubular hypertrophy. Stage II: persistent microalbuminuria, normal or elevated GFR, no clinical symptoms. Glomerular/tubular basement membrane thickening. Stage III: Significant increase in proteinuria (e.g., proteinuria > 0.5 g/24h), may have mild hypertension, and decreased GFR. Renal pathology shows K-W nodules. Stage IV: massive proteinuria, up to the degree of nephrotic syndrome. Stage V: Renal function continues to decline until end-stage renal disease. Urine microalbumin 220mg/24h should be stage II, belonging to the early stage of diabetic nephropathy, active treatment can slow down the disease progression. Diabetic nephropathy is one of the main causes of death in diabetic patients, need to be given targeted treatment under the guidance of specialized doctors.