1.What are the conditions to undergo IVF treatment? A: There are indications for IVF treatment: (1) the female partner has gamete delivery disorder due to various factors, such as bilateral tubal obstruction; (2) ovulation disorder; (3) endometriosis, and no pregnancy has been obtained through conventional medication or surgery; (4) the male partner has low, weak or abnormal spermatozoa, and no pregnancy has been obtained through intrauterine insemination, if the severity of the male partner’s factors is no longer suitable for obtaining pregnancy through intrauterine insemination; (5) immune infertility and unexplained infertility, and repeatedly obtained pregnancy through intrauterine insemination or other conventional insemination techniques; (6) the male partner has low, weak or abnormal spermatozoa. (5) Immune infertility and unexplained infertility, who have repeatedly failed to obtain pregnancy through IUI or other conventional treatments. 2. Is there any ectopic pregnancy in IVF? A: IVF technology itself cannot prevent ectopic pregnancy, nor can it reduce the risk of ectopic pregnancy. On the contrary, for those patients who may have tubal adhesions and other factors, the chance of ectopic pregnancy after IVF is slightly higher than that of the normal population; however, the chance of ectopic pregnancy is very low for day 5 or 6 blastocyst transfer. 3.What generation of IVF technology is used in the center? A: The current technologies in our fertility center are the first generation (conventional IVF technology), the second generation (ICSI: single sperm intracytoplasmic injection technology), and the proposed third generation (PGD: pre-implantation genetic diagnosis technology); there is no level between the generations, and they are suitable for different patients: the first generation is suitable for couples where the male partner’s semen is basically normal or poor; the second generation The second generation is suitable for couples with repeated fertilization failures or serious problems with the male partner’s semen; and the third generation is suitable for couples with genetic factors that require the selection of healthy embryos for transfer. 4. What is the preparation needed for IVF treatment? (1) Examination of the female partner: routine physical examination and gynecological examination; hysteroscopy, laparoscopy, immunological and other relevant examinations on the etiology of infertility; reproductive endocrine examination, examination of infectious diseases and sexually transmitted diseases (details are subject to the doctor’s orders). (2) Examination of the male partner: routine physical examination, routine and functional examination of semen, etiological examination, examination of infectious diseases and sexually transmitted diseases. (3) Preparation of documents: ID card of both parties, marriage certificate, original and copy of the family planning service certificate of the female partner, if foreign nationality or Hong Kong-Macau domicile, the family planning service certificate is not required. 6.What do I need to pay attention to when undergoing IVF treatment? A: You need to keep a calm mind and sleep well, keep warm, avoid colds and fevers, eat less seafood products, avoid contact with toxic and harmful substances such as newly renovated houses, use of cosmetics and perfumes, etc. Most importantly, follow the medical prescriptions for medication and follow-up examinations. 7.What are the steps and precautions for IVF? (1) First of all, after the doctor’s consultation and treatment, it is determined that you meet the indications for IVF and there are no contraindications, and your documents are all in order, then the pre-operative examination will be conducted first, and after the pre-operative examination is normal, you will come to the center to establish a medical record. (2) The doctor will make a plan according to your age and ovarian function, and determine the time to start your ovulation medication according to the patient’s condition. (3) After the start of ovulation promotion, you will usually return to the hospital for follow-up checkups, ultrasound and blood sampling 5-7 days after the medication is started. (4) After that, you should return to the hospital every 2-4 days to monitor the development of your follicles according to your doctor’s instructions. When the follicles are large enough, your doctor will inform you of the time for the HCG injection (night injection) and retrieve your eggs 36-38 hours after the night injection. (5) If your menstruation is delayed for 10 days after the injection, please return to the hospital for a check-up. (6) Due to the use of ovulation medication, your ovaries will increase in size, so do not do strenuous exercise during this period to avoid ovarian torsion. (7) After egg retrieval, embryos will be transferred to the center according to the doctor’s instruction. 8.Why do I need ovulation medication? During the natural menstrual cycle, several follicles develop each time, but only one of them eventually matures, while the others are atretic and die. The use of ovulation stimulating drugs can encourage more follicles to develop and mature together, so that more eggs can be retrieved and more embryos can be formed for selection. Ovulation stimulation allows the eggs that would otherwise fail to grow and die during the natural cycle to mature, thus not consuming additional eggs. 9. What are the common complications of IVF? (1) Ovarian hyperstimulation syndrome (OHSS) is caused by the use of ovulation-promoting drugs and the development of multiple eggs. After egg retrieval, some patients may develop ovarian hyperstimulation syndrome, which usually manifests as abdominal distension, oliguria, gastrointestinal discomfort, shortness of breath, etc. Ultrasound examination may reveal a significant increase in the size of the ovaries bilaterally, ascites (or even pleural fluid), etc. The symptoms may last for more than two months before they are eliminated if pregnancy occurs. If you experience any of these symptoms, you should return to the hospital or consult with the nearest clinic and contact the center. Ovarian hyperstimulation syndrome is the most common complication of the IVF process. Mild cases do not require special treatment, while severe cases require hospitalization for observation and treatment. Patients can eat normally. Patients with abdominal distension are advised to eat small and frequent meals with low sugar and high protein easily digestible food. Avoid overexertion, pressure on the abdomen and bruises. The vast majority of patients can safely pass through with positive psychological adjustment and general clinical management. (2) Multiple pregnancy is likely to occur in IVF with more than one embryo transferred. The incidence of multiple pregnancies is 15-20%. The incidence of maternal and infant complications in multiple pregnancies is higher than that in singleton pregnancies, which are prone to miscarriage, preterm delivery, hyperemesis, premature rupture of membranes, postpartum hemorrhage and other pregnancies; newborns are prone to intracranial hemorrhage, cerebral palsy, and whistling distress syndrome. Therefore, reduction of pregnancy is recommended for twin pregnancies, and reduction of pregnancy is necessary for 3 or more pregnancies. 10.Why does the success rate decrease with age? Generally speaking, fertility decreases gradually as the woman ages, especially after the age of 35, and this process is irreversible, and there are no drugs that can bring a woman’s fertility back to life. This is mainly due to the fact that the older a woman is, the worse her ovaries function and the fewer and poorer the quality of her eggs, for example, some studies have found that the older a woman is, the higher the incidence of chromosomal abnormalities in her eggs. 11. Why are some eggs not fertilized? Egg fertilization is a complex process, and scientific research does not yet fully understand the mechanisms involved in the entire process of fertilization. What is known about the fertilization process includes the maturation of the egg, the acquisition of sperm, the acrosome reaction and crossing of the zona pellucida, the fusion of the sperm with the egg membrane, the cortical reaction of the egg, the resumption of meiosis, and the formation of the male and female diploid nucleus. A problem in any of these processes can lead to failure of fertilization. In IVF technology, possible causes of egg non-fertilization include immature eggs, eggs that are mature but of questionable quality, and abnormal sperm morphology and function, thus affecting one or more of the above mentioned fertilization processes. 12.Why am I not getting pregnant when quality embryos have been selected for insertion into the uterus? The success rate of IVF is influenced by the quality of embryos, endometrial tolerance and other factors. In IVF, we will select high quality embryos for insertion into the uterine cavity, but it is impossible to achieve 100% implantation rate. This is because the current method of determining the quality of embryos is based on morphology, which means that we can predict whether the embryos are of good or bad quality based on the way they look. The probability of successful implantation is high. In addition, whether the embryo can be planted or not is also affected by the tolerance of the endometrium, which is like the land, if the land is not good, the seeds will not germinate and grow. 13.How many months does it take to do IVF from examination to transfer? A: For couples with normal test results and no need for special treatment or therapy, it usually takes about 2 months, the exact length may increase or decrease depending on the ovulation promotion program, individual’s physical condition and reaction to drugs. 14.When do both spouses need to be present at the same time during IVF treatment? A: The following situations require both spouses to be present at the same time: 1) on the day of initial consultation, both men and women will be examined at the same time; 2) on the day of file creation, both spouses need to sign an informed consent form and provide documents to establish medical records; 3) on the day of egg retrieval for the woman and sperm retrieval for the man; 4) on the day of embryo transfer. 15.Do I need to come to the center every day to monitor my follicles in a natural cycle? A: In natural cycles, when the follicles are close to ovulation, you may need to come to the center every day for follicle monitoring and blood sampling. 16.How is the expected date of delivery calculated for IVF? A: First of all, calculate the time of your last menstrual period: 17 days before transplantation is generally considered as the time of your last menstrual period, and 40 weeks after that time is your due date. For example, if you had your transplant on October 29, 2013, your last menstrual period will be October 12, 2013 and your due date will be July 19, 2014 (you can also calculate it by subtracting 3 from the month of your last menstrual period and adding 7 to the date). 17. If I am going to have a second transplant, should I go for a check-up during my menstrual period or wait for my period to clear? A: If you are sure about the transplantation plan, please follow the doctor’s instructions. If you are not sure, please follow up on the 2nd-3rd day of the second period after the last transplantation. 18.Is it true that more girls are born through IVF? A: The ratio of male to female in IVF is comparable to that of natural pregnancy, about 50% each. 19.What are the ovulation promotion drugs? A: Oral medications: Clomiphene, Letrozole, etc.; Injectable medications: Gonafen, Prilosec, Forteon, Lysine, HMG (urinary gonadotropin), etc.