Calf interosseous vein thrombosis is more serious. Calf interosseous vein thrombosis is also known as peripheral lower extremity venous thrombosis. Venous thrombosis is the abnormal clotting of blood in the lumen of the saphenous vein, blocking the venous lumen and leading to obstruction of venous return. If left untreated, pulmonary embolism (fatal or non-fatal) can occur in the acute stage, and in the later stage, the ability to live and work is affected because of the post-thrombotic syndrome. As the patient’s lesion was small in scope and triggered a mild degree of inflammatory response, the clinical symptoms were not obvious. Administering anticoagulant and platelet aggregation inhibiting drugs, encouraging the patient to do active movement of the limbs and leave the bed at an early stage are the main preventive measures. Treatment can be divided into two categories: non-surgical treatment and surgical removal of thrombus, which should be determined according to the type of lesion and the actual lesion stage. In case of intermuscular bundle vein thrombosis in the calf, patients should consult a doctor in time and standardize the treatment under the guidance of a professional physician to avoid further enlargement or dislodgement of the thrombus, which may lead to serious consequences.