X-knife is a kind of radiation therapy equipment, which adopts three-dimensional positioning in the human body. X-rays can accurately irradiate the tumor according to its growth shape, forming a neat edge between the tumor tissue and normal tissue, just like the one removed with a scalpel. X-knife treatment is not the same concept as surgical treatment; X-knife causes tumor tissue to die directly in the body instead of being taken out of the body. Therefore, X-blade has the advantage of no incision, no bloodshed, no pain and no risk. The X-blade is a linear gas pedal used in surgery, the treatment principle is similar to gamma knife, but it is generally not as sharp and precise as gamma knife, X-blade is more suitable for treating other parts of the body and larger lesions, X-blade can also be used with photosensitizers in treatment to enhance the killing effect of X-blade on tumor cells, reduce the radiation dose of X-blade and reduce complications. In addition, X-blade can also perform fractionated treatment to reduce complications such as cerebral edema and improve the treatment effect, especially for the treatment of larger malignant glioma and brain metastases. Finally, X Knife treatment is low cost and has considerable advantages for treatment of body organs, such as liver, lung, pancreas and other organs. Gamma knife treatment is more accurate and suitable for lesions smaller than 3cm, but also has its inherent defects, mainly the use of radioactive sources and the existence of decay, and the need to replace the drill source every now and then, so the cost is high, while the radioactive source of gamma knife is cobalt 60, which has a certain degree of pollution to the environment. Regardless of Gamma Knife or X Knife, as a means of treatment, if improperly applied, the same injury can occur, so the indications must be carefully selected and standardized treatment.