What are the possible impairments of thyroid function in pregnant women with pure autoantibodies to the thyroid gland? Overall, in antibody-positive patients, residual thyroid function can still meet the needs of pregnancy during the first trimester, but in late pregnancy, a sick thyroid can develop subclinical hypothyroidism or clinical hypothyroidism due to loss of compensation. How to treat and monitor pregnant women with positive thyroid autoantibodies (normal thyroid function)? The diagnostic criteria for a positive thyroid autoantibody is a titer of TPOAb above the upper limit of the reference value provided in the kit. A purely positive thyroid autoantibody without elevated serum TSH and decreased FT4 is also known as a positive thyroid autoantibody with normal thyroid function. Women with normal thyroid autoantibodies need to be monitored regularly during pregnancy. serum TSH should be tested every 4-6 weeks during the first half of pregnancy and at least once between 26 and 32 weeks of gestation. If TSH is found to be above the pregnancy-specific reference range, L-T4 therapy should be given.