Some beta-blockers such as atenolol may cause hypogonadism, which can be intervened with measures such as changing medications. Sexual dysfunction includes a variety of conditions, such as decreased frequency and subjective satisfaction with sexual intercourse, and absence of orgasm and libido. Certain blood pressure-lowering medications such as short-acting, low-selective beta-blockers such as atenolol may have an effect on beta2 receptors in the gonads, leading to the development of the sexual dysfunction described above. The occurrence of drug-induced sexual dysfunction can be mitigated by changing to a long-acting, highly selective β1-blocker, such as metoprolol succinate, which reduces the effect on androgen levels. However, it should be pointed out that hypertension, especially hypertension in young and middle-aged men, the primary hypertensive state may also cause abnormal penile cavernous regulation. It is recommended that daily attention be paid to monitoring the standardization and rational use of medication to maintain blood pressure at normal levels. The above drugs need to be used under the guidance of a clinician, and unauthorized use of drugs is prohibited. Sexual dysfunction, it is recommended to go to the hospital in a timely manner.