Impotence is erectile dysfunction, for fifty-year-old men with erectile dysfunction with premature ejaculation need to be treated, the patient can be improved through medication, psychotherapy, behavioral therapy and surgical treatment. 1. Medication: patients can take sildenafil, vardenafil and other drugs as prescribed by the doctor, which are the clinically preferred drugs used to treat erectile dysfunction. At the same time with dapoxetine, paroxetine and other selective 5-hydroxytryptamine re-extraction inhibitors, help to prolong the ejaculation, can make the premature ejaculation situation can be improved. 2. Psychological treatment: patients need to improve their psychological state, maintain a positive and optimistic mindset, avoid anxiety and tension, which can help to restore confidence in sexual life. 3. Behavioral treatment: The most common behavioral treatments include squeeze method, stop-motion method and functional-sexual therapy, which can improve the situation of premature ejaculation. 4. Surgery: If conservative treatment is ineffective, patients can choose surgical treatment, such as penile vascular surgery, dorsal penile nerve selective severance, etc., which can improve erectile dysfunction and premature ejaculation and other conditions. For men in their fifties with erectile dysfunction and premature ejaculation, they should go to a regular hospital for consultation and active treatment. If there is a primary disease, you also need to cooperate with the doctor together with the treatment. The above drugs should be applied under the guidance of doctors.