Pearly rash on the glans is usually treated without medication. Pearl rash, also known as pearly papules, belongs to a physiological developmental variant, not the category of sexually transmitted diseases. It may also be due to the long foreskin, the accumulation of foreskin scale stimulates the mucous membrane hyperplasia formation. Pearl rash occurs in the glans and the coronal groove connection, manifested as evenly arranged pearl-like small granular pimples. Generally pay attention to clean the foreskin scale, wash every day, some people will subside on their own. Some patients will remain unchanged for years or even decades. Pearl rash itself is not contagious, and has no effect on health, the general clinical treatment is not recommended. Some patients may also experience spontaneous regression after circumcision. Due to the aesthetic requirements of some people, often require treatment, general drug treatment is mainly to make it fall off necrosis for the purpose, often using 5% acetic acid solution coated with the affected area. Laser surgery is also available. The treatment can be left untreated in most cases as it may cause scar formation. Pearl rash needs to be clinically differentiated from early warts. In summary, the glans pearl rash is generally do not need treatment, and there is no harm, some people can subside on their own, clinical treatment of most of the patients because of the aesthetic requirements to take treatment, and do not make routine recommendations.