Typically, non-uniform fatty liver can present with signs and symptoms such as nausea, vomiting, fatigue, loss of appetite, epigastric pain, and jaundice. Non-uniform fatty liver, i.e., restrictive fatty liver, inhomogeneous fatty liver, refers to the presence of a large accumulation of fatty tissue in one area of the liver, while other areas of the liver are normal. A large amount of fat has accumulated in the liver cells, which interferes with the normal functioning of the liver. It can be caused by a high-fat, high-sugar diet, alcohol, obesity, metabolic syndrome, and type 2 diabetes. Non-uniform fatty liver has insidious onset, and may have symptoms such as fatigue, right upper abdomen discomfort, sleep disorder, constipation, etc.; some patients may be accompanied by liver enlargement and spleen enlargement; in the advanced stage, liver tissue is severely damaged, and liver function may show obvious decline, with liver palms, spider nevus, ascites, vomiting of blood, jaundice (yellow coloration of the skin and sclera, etc.), and hepatic encephalopathy. Patients with non-uniform fatty liver disease are recommended to consult a doctor in time for a clear diagnosis and targeted treatment under the doctor’s guidance.