Diabetes is very difficult to cure completely, but it can be clinically cured through five areas, namely pre-diabetes management, weight loss, intensive glucose reduction, metabolic surgery, and pancreas or islet transplantation. The management of pre-diabetes can be treated by diet and exercise. Weight reduction requires scientific weight reduction and good weight management. Intensive glucose lowering can be applied with hypoglycemic drugs or insulin. Metabolic surgical treatment can affect food intake, digestion and absorption to achieve weight loss. Pancreas transplantation or islet transplantation is mainly used for patients with type 1 diabetes. In addition, the outcome of diabetes depends on a number of factors such as the patient’s age, gender, duration of the disease, blood glucose, and weight. Therefore, for patients with diabetes mellitus, it is recommended to go to the hospital in time and standardize the treatment under the doctor’s guidance.