A healthy person has two kidneys with one million kidney units in each kidney. The function of the kidney units is to produce urine in which metabolic wastes are dissolved and excreted from the body. When kidney units are continuously lost for any reason, kidney function gradually declines. The reasons for the continuous progression of chronic kidney disease can be summarized in two ways. One can be summarized as the cause of chronic kidney disease has not been removed and continues to act on the kidneys; the other is that the kidneys themselves are losing working units spontaneously. When there are damaging factors acting on the kidneys, it will lead to a continuous loss of kidney units. A few frequently encountered examples: (1) high blood pressure: arterial blood flows into the kidneys so that the kidneys can play the role of filtration and excretion of metabolic waste. When the blood pressure is too low, not enough blood flows into the kidneys, called renal underperfusion, the role of the kidneys in filtration and excretion of metabolic waste can not be fully played, which will lead to the accumulation of metabolic waste in the body; and when the blood pressure is too high, the renal perfusion pressure is too high, called renal hyperperfusion, resulting in kidney unit damage, and over time, kidney units will continue to be lost. Hypertension can cause kidney disease, and kidney disease can also cause hypertension, hypertension and kidney disease are mutually causal, forming a vicious circle. Therefore, it is very important to control blood pressure in patients with chronic kidney disease. (2) High blood sugar: kidney disease combined with diabetes, whether the kidney disease is caused by diabetes or other causes, if poor control and blood sugar increases, it will increase the filtration burden of the kidney, resulting in the gradual loss of kidney units over time. So it is very important to control blood sugar in the right range. (3) Proteinuria: proteinuria itself is a sign of kidney damage and a substance that causes kidney damage. It is important to try to take measures to make the urine protein as low as possible. However, due to the limitations of current medical technology, it is difficult to subside the urine protein in patients with chronic kidney disease, and that effort to seek a cure for chronic kidney disease is futile. Chronic kidney disease patients should not believe in some unscientific propaganda. (4) Medications: Most medications are excreted by the kidneys, so just taking medications or infusions will increase the burden on the kidneys. Often people claim that they are taking kidney-protecting health care drugs, which is actually undesirable. Some health care drugs can even directly damage the kidneys, leading to acute kidney failure, or manifestation of kidney failure only after several years. For example, in the past few years, the use of a lot of gentian diarrhea liver pills containing aristolochic acid ingredients, after taking does not immediately appear to decline in kidney function, many patients are several years or even a dozen years after the discontinuation of the drug gradually appear kidney failure. Another drug that causes chronic kidney disease is painkillers, long-term use of painkillers due to pain symptoms can appear chronic kidney disease. Therefore, patients with kidney disease should try to reduce the type and number of drugs used, and use only the necessary drugs. (5) Infection: When any infection occurs, including upper respiratory tract infection, pneumonia, although these infections do not occur in the kidneys, these infections can lead to systemic inflammatory conditions, and inflammatory factors can act on the kidneys to aggravate the already damaged kidneys, resulting in the loss of kidney units; or the drugs used at the time of infection may cause kidney damage; or the infection may lead to a disruption of the immune mechanism, aggravating the original self (6) Strenuous exercise (6) Strenuous exercise: Strenuous exercise produces a large amount of metabolic waste, which increases the burden on the kidneys. Therefore, patients with chronic kidney disease should avoid strenuous exercise. This is not to say that patients with chronic kidney disease do not need to exercise, but to moderate. Under normal circumstances, not all kidney units have given full play to their role of excreting metabolic waste, as long as it is ensured that metabolic waste can be excreted adequately. The size of the kidney of a healthy young man is comparable to the size of his fist, and as he grows older, affected by a number of factors, the kidney units will continue to decrease and the kidney volume will gradually become smaller. Patients with chronic kidney disease have a faster rate of kidney unit reduction and kidney shrinkage than the general population. This is partly because the factors that cause kidney disease are not under control and are still damaging the kidneys; on the other hand, even if patients with chronic kidney disease have adequately controlled the factors that cause kidney unit loss in the kidneys mentioned above, their kidney unit loss is faster than that of the general population. This is because patients with chronic kidney disease have fewer kidney units, and each kidney unit has to work hard to ensure the full excretion of metabolic waste, and over time the kidney units are “exhausted”; with the continuous loss of kidney units, one day even if all kidney units are working at full capacity can not fully excrete metabolic waste, the metabolic waste in the blood is If the kidney units are further lost, the azotemia becomes more and more serious and finally reaches uremia, and dialysis treatment has to be started. Therefore, to slow down the progression of kidney disease, it is essential to slow down the rate of kidney unit loss. To slow down the rate of kidney unit loss, we need to treat the factors that cause kidney unit loss mentioned earlier. Patients with chronic kidney disease also need to cooperate with dietary therapy, which aims to reduce the kidney burden caused by unreasonable diet, and the principle is to limit protein intake on the basis of ensuring comprehensive and adequate nutrition. Patients need to talk to their physicians about how to slow down the progression of kidney disease through dietary control.