After a skin infection, the pathogen stimulates the body to produce a series of immune responses, which can lead to kidney disease. Infectious skin diseases, including impetigo, dermatitis, rash with infection, pyoderma, boils and carbuncles, scabies, and herpes, can be followed by renal disease after various acute and chronic infections. A typical nephropathy is acute glomerulonephritis. Others can also cause nephrotic syndrome, IgA nephropathy, and allergic purpura nephritis. The relationship between skin infections and kidney disease is often not taken seriously by patients or even doctors, resulting in delays in the best time for diagnosis and treatment, resulting in adverse consequences. The following clinical manifestations of typical acute glomerulonephritis are described as follows: The general clinical course is that after skin infection, clinical incubation for 14-21 days (usually not more than 4 weeks), followed by the symptoms of kidney disease, including 1. hematuria: both carnal hematuria and microscopic hematuria can occur, with carnal hematuria accounting for about 40%. 2. Proteinuria: The amount of urine protein is low in pediatric patients and is non-nephrotic range of proteinuria (urine protein <3.5g/24h), while the amount of urine protein can be higher in adult patients. Most urine protein turns negative within a few weeks. 3. Edema: typically facial edema, then spreading to generalized edema. Most of the patients' edema subsides on its own in about 2 weeks. 4. Hypertension: mild to moderate hypertension is seen in 80% of patients. 5. Renal impairment: There may be a mild increase in blood creatinine. After the edema subsides, the blood creatinine can return to normal. Therefore, once the skin infectious diseases, we should pay attention to whether the kidney lesions, so as to timely detection and treatment.