Many women are apprehensive when they take their first IVF pregnancy test, and they even use the early pregnancy test early, but who knows that even after winning the lottery, the two bars will disappear slowly, and the good embryo will disappear at the drop of a hat. This time, we will talk about the biochemical pregnancy that makes the baby “once had, but not forever”. In the process of IVF, we often hear the term “biochemical pregnancy”, what exactly is biochemical pregnancy in IVF? 1. What is biochemical pregnancy? A biochemical pregnancy is often referred to as a biochemical pregnancy, also known as an insidious miscarriage, in which the serum HCG is greater than normal, but no gestational sac is seen on ultrasound examination, and then the pregnancy is terminated spontaneously. The fertilized egg begins to implant on day 6-7 after fertilization, and the differentiation of trophoblast cells into cytotrophoblast and syncytial trophoblast cells begins to secrete human chorionic gonadotropin (HCG) on about day 9, which is completed on day 11-12. The implantation goes through 3 stages: localization, attachment and implantation. Problems at any point after implantation can lead to eventual failure of implantation and the occurrence of a biochemical pregnancy. 2. Is “biochemical pregnancy” the same as miscarriage? A biochemical pregnancy is a subclinical miscarriage and should be distinguished from other miscarriages due to illness or accidents. If it is a biochemical pregnancy, it will not have a big impact once in a while. It will return to normal after the next menstrual period and will not affect future pregnancies. 3. Why does a biochemical pregnancy occur? 1) Thickness and tolerance of the endometrium: The endometrium is the “soil” for embryo implantation. The thickness, shape (e.g. endometrial polyp) and tolerance of the endometrium affect the pregnancy outcome. 2) Egg quality: Egg quality directly affects the quality of the embryo and is thus associated with the occurrence of biochemical pregnancy. 3) Embryo quality: the quality of the embryo often influences pregnancy outcome through its ability to implant and its ability to develop after implantation. 4)Embryo chromosomes: embryo chromosomes have an influence on embryo quality. 5) Maternal hormone levels: Various hormones in the mother have an effect on the various processes of ovulation, fertilization, and implantation, but the mechanisms related to hormone levels and biochemical pregnancy are not well understood. The relationship between estradiol (E2) levels and biochemical pregnancy is currently controversial. 6) Psychological factors are stressful, excessive mental tension, and psychological state directly affects embryo implantation. 7) Immunological factors may also influence the occurrence of biochemical pregnancy. 8)Biochemical pregnancy may be related to male age and semen quality. 9) Biochemical pregnancy is related to previous biochemical pregnancy or history of miscarriage. 4) What should I pay attention to in order to prevent and avoid biochemical pregnancy? 1) Acute infectious diseases should wait for a period of time to heal before pregnancy. Patients with chronic diseases should be treated and stabilized and approved by a specialist before pregnancy. 2) For couples with a history of miscarriage, they should go to the hospital in time to find out the cause of the miscarriage, and whichever of them has the problem, they should be treated in time and have the baby after the cure. 3) Women who are already pregnant should avoid exposure to harmful chemicals such as benzene, mercury and radiation. Early pregnancy should go to public places less often to avoid viral and bacterial infections. 4) During early pregnancy (within 12 weeks of pregnancy), in addition to paying attention to diet and hygiene and avoiding excessive exertion, you should also avoid excessive stress and maintain emotional stability to help settle the fetus. Do not have intercourse in the first 3 months of pregnancy and avoid long distance travel. 5) Avoid bad habits in life, such as smoking, alcoholism, staying up late, overworking, etc., which can have an effect on sperm and eggs. So this aspect must be adjusted. 6) Necessary TCM adjustments will help to produce a healthy and smart baby. 7) Supplementation of necessary nutrients, all the nutrients needed by the fetus are supplied by the mother, if the mother’s nutritional intake is insufficient or unbalanced, it will directly affect the developmental status of the fetus. 5. Will it be successful next time? IVF failure is a very heavy blow to women who, in addition to facing this failure, are more concerned about the chances of success if they receive the next treatment. It has been suggested that biochemical pregnancy is a positive predictor of the success of subsequent IVF treatment. Patients who experienced early embryo loss were found to have more high-quality embryos and frozen embryos and were more likely to be successful with the next IVF. It has also been reported that patients with biochemical pregnancy have a significantly higher probability of being able to continue the pregnancy next time compared to the total IVF population. 6. How long does it take to get pregnant after a biochemical pregnancy? Doctors and patients do not want to see a biochemical pregnancy, but do not panic when you encounter such a situation, it is the result of natural selection of superiority and inferiority, biochemical pregnancy can be said not to be a real pregnancy, it will not have an impact on future pregnancies, and you can consider getting pregnant again next month, not to mention the need to clear the uterus. If you have many biochemical pregnancies, you have to actively face the causes of biochemical carefully analyze, find problems and solve them, and continue to work hard to achieve a long life with your baby!