Cleft lip and palate malformation is the most prevalent congenital malformation in China, with an incidence of about 1‰ to 2‰. It is a multifactorial genetic disease related to genes and environment, and its specific etiology is still inexact.
The cause of cleft lip and palate is not exact. It is generally accepted that cleft lip is a multifactorial genetic disease, and the specific causes can be divided into two categories: genetic factors and environmental factors, which include maternal environment, infections, drugs, poor lifestyle habits, and nutrition. There is still no definite answer as to what causes cleft lip or what causes can be avoided to avoid it.