Most people who suffer from cholecystitis or gallbladder stones usually choose to have their gallbladder surgically removed in order to achieve a cure. After cholecystectomy, doctors always instruct patients to take preventive care to prevent abdominal pain, bloating and diarrhea after surgery. However, you may not know that in addition to the above common complications after cholecystectomy, colorectal cancer may also occur secondary to gallbladder removal. Therefore, patients should pay attention to self-care after gallbladder removal to prevent secondary colorectal cancer. The human gallbladder has the function of concentrating, storing and emptying bile. Most of the bile secreted by the liver is stored in the gallbladder, and the function of bile is to emulsify fat and promote fat absorption. After we eat, especially after eating food containing a lot of fat, the gallbladder will contract and discharge the stored bile into the intestine to play a role in helping digestion and absorption. If the gallbladder is removed, the bile secreted by the liver has no place to be stored, so the bile will enter the intestine directly day and night, and the bile will be decomposed by the bacteria in the intestine to produce carcinogenic “secondary bile acids”. Foreign scholars have found that secondary bile acids have strong oxidizing effects, which destroy the genes of cells, reduce the resistance of cells to damage and undergo malignant transformation, and these factors will promote the development of cancer in the colonic mucosa. However, many patients often unknowingly fall into a misconception that they can rest easy after gallbladder removal as long as they take care of their diets, but in fact, there are data showing that the incidence of colorectal cancer after gallbladder stone and cholecystectomy is significantly higher than that of normal people. Of course, although gallbladder removal may induce colorectal cancer, patients who have undergone gallbladder removal should not be too alarmed, as long as they have a regular diet, regular colonoscopy, observe the change of stool shape and whether there is bleeding, and early detection and treatment, they can still avoid the development of the disease. Many people think that colonoscopy is uncomfortable, but in fact, colonoscopy itself is generally not too painful unless the patient’s colon is too long or the examiner is not skilled. It is important to understand that colonoscopy is not only a diagnostic tool, but also a treatment and prevention tool for colorectal cancer. Compared with having colorectal cancer, the pain of colonoscopy is obviously insignificant. Experts suggest that colonoscopy should be performed once every 2 to 3 years after cholecystectomy, and those who have symptoms should be followed closely in advance so that colorectal cancer can be detected early and effective treatment measures can be taken in time.