Topical medications for canker sores and pain include mupirocin ointment, erythromycin ointment, and fusidic acid cream. 1. mupirocin ointment: this drug is a local topical antibiotic for impetigo, boils, folliculitis and other skin infections, for canker sores and pain have a certain effect, there may be local burning sensation, stinging sensation and itching and other adverse reactions, generally can be relieved by themselves. 2. Erythromycin ointment: the drug can be used for impetigo and other purulent skin diseases, as well as small burns, ulcer surface infections and the treatment of common acne. There may be burning sensation, redness, swelling, itching and other allergic symptoms, allergies should be discontinued and residual medication should be washed, and medical attention should be sought if symptoms are severe. 3. Fusidic acid cream: mainly used for impetigo, boils, carbuncles, canker sores, beard sores, sweating, ringworm, folliculitis, common acne and other skin infections, may have contact dermatitis, erythema, itching and other adverse reactions. Note that the drug should not be used for long periods of time or over large areas. In addition, commonly used drugs include Ruyi Jinhuang Cream, ichthyol ointment, 0.5% vital iodine gauze, etc. Patients are advised to use the drug under the guidance of a doctor, and not to use the drug blindly on their own, so as not to cause discomfort.