Pityriasis rosea is a common self-limiting inflammatory skin disease. The etiology is unknown and is related to the immunity of the body and viral (especially coxsackievirus and herpes virus) infections, etc. More than 75% of patients develop the disease between the ages of 10 and 35, and some patients have symptoms of upper respiratory tract infections such as colds and sore throats before the onset of the rash (rash appearance). The clinical symptoms of pityriasis rosea are not serious, most patients only show skin round or oval rash, a few patients initial rash for papule, maculopapular rash, rash can spread all over the body, to trunk and proximal distribution of the extremities more common, some accompanied by pruritus, pruritus vary in severity. Very rarely recur after healing. The color of the rash of pityriasis rosea can be light red or light brown, the typical rash is 1-2cm oval patch-like, the long axis of the rash is distributed along the skin line, and has the typical collar sign. The atypical rash should be distinguished from syphilitic rash, punctate psoriasis, coin-shaped eczema, drug rash, etc. Therefore, patients with atypical rash should be checked for syphilis antibodies to exclude syphilis. Although the name of “pityriasis rosea” is very nice, but the same will bring many troubles to the patient, life brings unchanged. Some patients’ disease continues for a long time, the disease has not healed for several years without treatment, or the patient who has not healed after exertion or cold aggravates the disease. Most patients can be cured by giving only antihistamines and topical glucocorticoids, while some patients need to combine antiviral drugs or macrolide antibiotics. Some doctors use glucocorticosteroids for a short time, but I usually use glycopyrrolate (trade name: Mennen) instead of glucocorticosteroids. A small number of patients who are not sensitive to drug therapy may also be treated with UVB (narrow spectrum medium wave ultraviolet) irradiation. We also usually choose different medications according to the duration of the disease: patients within one month of onset are routinely treated with antiviral drugs combined with antihistamines and topical glucocorticoids; patients with onset of disease beyond one month, when viral infection is excluded, are treated with macrolide antibiotics combined with antihistamines and topical glucocorticoids.