SLE is common in women of childbearing age, and marriage and childbearing is a major life event for these patients. The following is a list of precautions for lupus patients in preparing for pregnancy, getting pregnant and breastfeeding. The best time for patients to get married is when their condition is stable and there is no serious damage to internal organs. If lupus patients have children or their disease is in the active stage, they should use strict contraception. Contraceptive pills containing estrogen or estrogen-progestin mixture should not be used; contraceptive pills containing only progestin can be used (which seldom make the disease recur but are more likely to cause drug-related complications); birth control rings should not be used (to avoid intrauterine infections); do not predict the safe period based on the menstrual cycle; and it is better to use mechanical barriers, such as vaginal diaphragm or condoms. Condoms. Lupus patients can not get pregnant: (1) the first 2 years of the onset of lupus; (2) the condition is not yet under control (using a large amount of hormones) or not yet stabilized for a long period of time, because more than 60% of the condition worsens when pregnancy occurs during the active period, but only 7% of the condition worsens when the condition is under control and only a small amount of hormones are used in the pregnancy. In addition, pregnancy during the active period is associated with a high risk to the fetus; (3) those with vital organ involvement such as kidney, brain, heart and lungs; (4) those with active renal disease or blood creatinine >2mg/ml (176.8umol/L). Timing of pregnancy in lupus patients: (1) no involvement of vital organs; (2) stable remission for >1 year; (3) prednisone maintenance <10mg/day; (4) no immunosuppressive drugs for at least 6 months. Before pregnancy: (1) Consultation with obstetrics and gynecology department: check the relevant items such as anti-Toxoplasma gondii antibody; (2) Consultation with rheumatology department, and be fully prepared: because 10-50% of patients have relapse of the disease in the middle of pregnancy or a few months after delivery, lupus can cause miscarriage, preterm labor, stillbirth, and intrauterine growth retardation of fetus, etc., and those who are positive for serum antiphospholipid antibody are prone to miscarriage and fetal death in the womb. Attention after pregnancy: (1) Go to obstetrics and rheumatology regularly, and closely monitor the activity of lupus; (2) The first and second trimesters of pregnancy are the key observation period, and increase or decrease the hormone as appropriate: miscarriage is easy to happen in the first trimester, and relapse is easy to happen in the second trimester and after delivery, so don't use the medication arbitrarily, and do not adjust the hormone dosage of the stabilized patients.