In 1970, Grover reported a group of acquired diseases of unknown etiology characterized by papules and blisters, which were named Transient acantholytic dermatosis TAD (also known as Grover’s disease) because of the short duration of the disease and the histopathological changes of marked acantholysis. The cause of the disease is still unknown, but it is clear that it is not related to genetics or autoimmunity. Some physical and chemical factors such as sun exposure, sweating, fever, prolonged bed rest, hemodialysis, Malassezia and Trichinella infections can induce or exacerbate the disease. Scheinfeld N et al. also found that the disease is seasonally related, and the incidence of the disease in winter is four times more than that in summer. The disease can also coexist with eczema, psoriasis, AIDS, leukemia, kidney transplantation, gastric cancer, thymus tumor, systemic sclerosis, leukemia and other diseases. The disease is prevalent in middle-aged men over 40 years of age, clinically, herpes papules are predominantly found in the vicinity of the clavicle, the root of the neck, the sternum, the upper dorsal region, but also can be seen in the epigastric region, the head, face and limbs, self-consciously itchy, generally no systemic symptoms, laboratory examination may appear eosinophilia, total IGE increased, and the diagnosis of which is mainly based on the histopathological examination. Pathologic manifestations of limited basal cell layer on the fissure or blisters, and follicular keratosis, common type pemphigus, familial chronic benign pemphigus histology similar. The pathologic changes of this disease are divided into 5 types: (1) Darier’s disease-like type: focal spiny loosening above the basal layer, fissure formation, follicular spiny loosening can be seen in the hair follicle. Sometimes poorly keratinized cells and spongy edema are seen throughout the epidermis, while Darier’s disease is seen as vertical hyperkeratosis. (2) Hailey-hailey disease-like pattern: “battlements collapse”-like changes can be seen, the spiny layer above the basal layer is loosened, the spiny loosened cells and a few poorly keratinized cells can be seen, and spongiotic edema can be seen occasionally. The difference with Hailey – hailey disease is that there is no obvious thickening of the epidermis, and the spongiosis is focal. (3) Pemphigus vulgaris-like pattern: limited spongiosis over the basal cell layer, with spongiotic cells in the fissures and no dyskeratotic cells. These pathologic changes are less severe than in the “normal pemphigus-like type”. (4) Sponge edema: sponge edema and intra-epidermal blisters are seen, and echinodermolytic cells are seen in the blisters. Compared with atopic dermatosis, spongiosis and acantholysis coexist in this disease, and multiple histopathologic changes can be seen in lesions of the same patient. (5) Deciduous pemphigoid: Superficial acantholysis, often in the uppermost part of the epidermal hair layer. In contrast to “deciduous pemphigoid”, the spiculolysis is more pronounced and reaches deeper into the epidermis.Hautarzt et al. studied 21 cases of this disease and found that the most predominant type was Darier’s. In the treatment of this disease, topical treatments can be applied to the epidermis and the skin. For treatment, topical glucocorticoids or retinoid ointment can be used locally, and systemic medication with retinoids and glucocorticoids is the most effective.Miljkovic J et al. treated the disease locally with calcipotriol ointment, and systemically gave a small dose of Avian A capsules, which resulted in a significant symptomatic relief after 1 week, and a basic cure after 3 weeks, and no recurrence.Moderer M et al. and Quirk CJ et al.[10] each cured the disease with Avitamin A in combination with phototherapy each cured a case of the disease.Keohane SG et al, Mota AV et al each treated the disease with single topical calcipotriol and also achieved good results.Helfman RJ treated 4 cases of the disease with isotretinoin and 3 cases were cured after 10 months of treatment and 1 case was cured after 8 months of treatment but relapsed soon after discontinuation of the drug. Treatment of the disease with simple topical glucocorticoids and emollients, tacalcitol, and trichloroacetic acid has also been reported. In this case, there were no obvious triggers such as sun exposure, sweating, fever and infection before the onset of the disease, the age of onset was relatively young, the patient was a female, and the rash was mainly concentrated on the extremities, while there was no obvious rash on the trunk, all these features were somewhat different from the characteristics of the previously reported cases. This case was clearly diagnosed as “temporary acantholytic dermatosis” by histopathologic examination, and belonged to the common type of pemphigus. We used internal and external glucocorticoid treatment, and the patient’s condition was rapidly relieved, indicating that glucocorticoid can be an effective treatment for this disease, and that more effective and alternative treatments need to be further observed and verified.