The principle adopted in the insulin release test is the normal human process of insulin release.
The insulin release test is based on the principle that after a patient takes a quantitative oral dose of glucose on an empty stomach, the body’s blood glucose rises and stimulates insulin secretion from the pancreatic beta cells. The increase in islet function is accompanied by a gradual increase in insulin release and an increase in c-peptide levels, which helps to identify the typing of diabetes and guide the treatment of diabetes. The test method is also relatively simple. Patients who are recommended to take the insulin release test can have a proper regular diet for the first three days. On the day of the test, 75 grams of glucose should be taken, and the patient’s insulin level should be tested gradually at four time points after taking the glucose, and the insulin level should be crossed out four times. The insulin level in normal people often appears to peak half an hour to one hour after taking glucose, and is often 5-10 times higher than the basal level. If there is some abnormality in the patient’s own islet function, the normal insulin is not effectively released, and the test curve shows a low level, it means that the islet function is severely broken, and the clinical significance is that the islet secretion is absolutely insufficient, and insulin lifelong treatment is needed. If the curve rises slowly and the peak occurs in 2 to 3 hours, it indicates that the islet secretion is relatively insufficient, and this type of patients usually have better results after systematic treatment and lifestyle adjustment.