IVF is the common name for the in vitro fertilization-embryo transfer technique, a process in which the egg and sperm are removed separately, placed in culture to fertilize them, and then the embryo is transferred back into the mother’s uterus to develop into a fetus. This includes babies successfully conceived and delivered after conventional in vitro fertilization and embryo transfer techniques, intracytoplasmic single sperm injection techniques, and preimplantation embryo genetic diagnosis techniques. The etiology of infertility in both partners such as ovulation disorders, pelvic factors and male factors are associated with the occurrence of adverse pregnancy outcomes in the mother and fetus. Health education and guidance during pregnancy, screening and prevention of common maternal and fetal abnormalities and diseases during pregnancy and delivery, elimination and reduction of risk factors for adverse pregnancy outcomes, protection of maternal and fetal health and reduction of maternal mortality and birth defects are the key points of IVF pregnancy health care, based on the relevant guidelines and norms developed by academic groups in China and the United States, the United Kingdom and Canada, the following are summarized The following are important points. I. Week of pregnancy, number of maternity check-ups and management of high-risk pregnancy: 1. 2, the week of pregnancy and the number of maternity check-ups: maternity check-ups are conducted at 6-13 weeks +6, 14-19 weeks +6, 20-24 weeks, 24-28 weeks, 30-32 weeks, 33-36 weeks, 37-41 weeks of pregnancy, and the number can be increased according to the condition. 3. High-risk pregnancy management: IVF pregnancy is in the category of high-risk pregnancy, and the need for referral is chosen according to the high-risk pregnancy score after the establishment of the file. It is recommended that the hospital for inpatient delivery be a level II or higher health care midwifery facility. Prenatal screening and prenatal diagnosis strategies Prenatal screening for fetal abnormalities is mainly for aneuploidy chromosomal abnormalities, neural tube defects, fetal structural malformations and congenital heart disease. Prenatal diagnosis of fetal diseases mainly includes chromosomal abnormalities, sex-linked abnormalities, inherited metabolic defects and fetal structural abnormalities. Prenatal screening: (1) Early pregnancy (10-13+6 weeks of gestation) combined prenatal screening: including age, ultrasound indicators, serological indicators, mainly screening for fetal trisomy 21 and trisomy 18, because of the impact of assisted reproductive technology on early pregnancy serological indicators, the choice should be considered under the guidance of doctors to weigh. (2) Middle pregnancy (15-20+6 weeks of gestation) serologic screening: screening for fetal trisomy 21, trisomy 18 and open neural tube defects. (3) Ultrasound system screening in early and mid pregnancy: to detect severe lethal malformations. All IVF pregnant women must be screened at least once from 18-26 weeks of gestation. (4) Fetal heart echocardiography: further screening for fetal congenital heart disease at 20-22 weeks of gestation if indicated. 2.Middle pregnancy (13-27 weeks of gestation) chromosome aneuploidy non-invasive prenatal testing: it is suitable for pregnant women with high risk of prenatal screening, unsuitable and refusing to do prenatal diagnosis, or used when the capacity of prenatal diagnosis service is even less. Currently, it mainly examines fetal trisomy 21, trisomy 18 and trisomy 13. China is about to issue the relevant norms, and it is generally recommended to use it after the second level of ultrasound examination in early and middle pregnancy. Pregnant women with indications for prenatal diagnosis and prenatal ultrasound examination suggesting fetal structural malformation should be used with caution. 3.Prenatal diagnosis: It is suitable for those who have indications for prenatal diagnosis. (1) Amniocentesis to check fetal karyotype (17-23 weeks of gestation): mandatory after prenatal embryo genetic diagnosis techniques (PGD, PGS). (2) Others: including molecular cytogenetics prenatal diagnosis, fetal ultrasonography and fetal MRI. Prevention and treatment of common maternal and fetal diseases during pregnancy and delivery 1. Preterm delivery: refers to delivery between 28 and less than 37 weeks of gestation. The etiology and pathogenesis are unknown, and are related to advanced age, history of miscarriage, multiple births and in vitro fertilization. In singleton pregnancies at 20-24 weeks of gestation, if there is a previous history of miscarriage and other high-risk factors, the risk of preterm labor can be assessed by ultrasound measurement of cervical length, and measures such as natural progestins and cervical cerclage can be used to reduce the risk of preterm labor as appropriate. Once preterm labor is approaching, hospitalization is needed to protect the health of mother and child. 2. Gestational combined diabetes (1) Screening: fasting glucose or 75g glucose tolerance test (OGTT) must be selected to screen for gestational combined diabetes during the first obstetric examination and 24-28 weeks. (2) Prevention and treatment: to prevent the occurrence of gestational combined diabetes through dietary intervention and physical exercise to maintain reasonable weight gain during pregnancy. Pregnant women with gestational combined diabetes need medical nutrition and exercise therapy, and those with indications can be given insulin therapy to reduce maternal and infant complications. 3. Infectious diseases (1) Screening: HBsAg, syphilis spirochete and HIV screening must be selected for the first obstetric examination, and if they have been examined in the first 6 months of pregnancy, they can be examined without repeating. Pregnant women with high-risk factors can select targeted screening for Toxoplasma gondii, cytomegalovirus, and herpes simplex virus infection. (2) Measures to prevent infection during pregnancy: mainly keep away from infected people, wash hands frequently, cook meat until it is cooked; tetanus or influenza vaccination can be given during pregnancy. (4) Other pregnancy complications: pregnant women undergoing IVF are at high risk of developing hypertensive disorders during pregnancy, placenta praevia, placenta abruptio, fetal growth restriction, abnormal thyroid function and other diseases, which should be detected as early as possible during regular maternity checkups and treated promptly. Dietary intervention and exercise for weight management 1. Micronutrient and vitamin supplementation: Most minerals and vitamins can be obtained through balanced nutrition during pregnancy. Continue to take multivitamin containing folic acid in early pregnancy until delivery; supplement elemental iron 60-100mg/d if hemoglobin <105g/L and serum ferritin <12ug/L from mid-pregnancy, and calcium 600mg/d from mid-pregnancy. 2. Total recommended reasonable weight gain during pregnancy: mainly to prevent the occurrence of adverse maternal and child outcomes. (1) According to the single and twin fetuses and the presence of pregnancy comorbidities and complications, individualized dietary nutrition plan should be adopted under the guidance of doctors. (2) The total amount of weight gain during pregnancy should be recommended according to the pre-pregnancy body mass index (BMI). Pregnant women who are underweight and overweight and obese should have reasonable pregnancy weight gain; early, middle and late pregnancy should have reasonable pregnancy weight gain; insufficient pregnancy weight gain is associated with maternal blood volume deficiency and low birth weight babies; excessive pregnancy weight gain is associated with gestational combined diabetes, preterm delivery and hypertensive disorders during pregnancy. 3. Physical exercise: If there are no obstetric or medical contraindications, routine light to moderate exercise is encouraged, 3-4 times a week for more than 10-30 minutes each time, with walking being appropriate to help maintain the health of the cardiovascular system and muscles during pregnancy and delivery. V. Other: 1. Psychological adjustment: Maintain 7 hours of continuous sleep every night, if sleep deprivation for more than two consecutive weeks it is recommended to seek medical help. 2. Home monitoring (1) Pay attention to the aura of preterm labor: backache, increased vaginal discharge, abdominal cramping, vaginal redness, etc. (2) Fetal movement count: late pregnancy fetal movement count ≥ 6 times / 2 hours is normal. If there is no indication for cesarean delivery, but the pregnant woman and her family still insist on cesarean delivery after weighing the pros and cons, it is appropriate to choose to deliver after 39 weeks of pregnancy and to prevent postpartum hemorrhage.