Diabetic patients with difficult to heal wounds usually need to clean the wound, control infection and adjust blood sugar to help wound healing. 1. Diabetic patients are generally more prone to infections because of the high glucose content in their blood. If the patient’s wound is infected, the redness, swelling, ulceration or pus around the wound is not conducive to wound healing, and at this time, the doctor needs to clean out the necrotic structures in time, and re-sanitize and change the dressing on the wound. 2. In addition to the infection around the wound, the infection may also cause systemic symptoms, which will also affect the wound healing. Therefore, effective anti-infection treatment is needed. Bacterial culture and drug sensitivity test can be done at an early stage to choose effective antibiotic treatment. 3. Poor glycemic control may also affect wound healing, and glucose-lowering medications such as metformin, acarbose, etc. or insulin can be used to adjust blood glucose under the guidance of a doctor. Diabetic patients with difficult to heal wounds, should contact the doctor in a timely manner, under the guidance of the doctor according to the patient’s condition standardized treatment.