Nine-valent vaccine refers to the nine-valent HPV vaccine, which can usually be given when the plantar warts are in a stable stage, and is usually not recommended when the warts are in an acute flare-up stage. Plantar warts are common warts that occur on the bottom of the foot, and when they are in a stable stage, they usually don’t cause uncomfortable symptoms. The HPV vaccine does not usually interfere with the efficacy of the vaccine, and the vaccine does not cause damage to the body. Therefore, when the plantar warts are in a stable stage, the HPV vaccine can usually be given. When plantar warts are in the acute exacerbation stage of the disease, it will cause surface keratinization, capillary rupture bleeding and other abnormalities, and when combined with infection, it will often cause painful symptoms. The HPV vaccine may aggravate the condition and may interfere with the effect of the vaccine. Therefore , when the plantar warts are in the acute exacerbation period, it is generally not recommended to take the nine-valent HPV vaccine. Adverse reactions to the HPV vaccine include redness and swelling at the vaccination site, fever, nausea, dizziness, fatigue, menstrual disorders, dyspepsia, and skin rash. For people who are allergic to the vaccine components, patients with severe fever, patients with thrombocytopenia, patients with abnormal blood clotting function and other people need to prohibit the nine-valent HPV vaccine. When you have plantar warts and need to take the HPV vaccine, you need to actively consult a professional doctor. At the same time, after the vaccine, if any discomfort occurs, you need to consult a doctor in time.