Patients with chest tightness and breath-holding when they get angry are affected by mood swings, which affect the neurohumoral regulation, causing vasoconstriction and diastole to be affected, which can lead to insufficient blood supply to the heart or poor circulation and respiratory system. From the perspective of traditional Chinese medicine, chest tightness and breath-holding when angry belong to the evidence of qi stagnation in the heart and chest, the main manifestations of which are heart and chest fullness and stuffiness, vague pain bouts, and pain in a fixed place, as well as the desire to sigh at times, which is easily triggered and aggravated when encountering emotional and mental disorders, and is seen to have chest distention and stuffiness, and the stuffiness and pain can be relieved after getting belching or dampness, as well as the thin and greasy tongue coating and thin and string-like pulse. To treat Qi stagnation in the heart and chest, it is necessary to dredge the liver and regulate Qi, invigorate blood circulation, and the representative formula is Chai Hu Dredge Liver San, which consists of Chen Pi, Chai Hu, Citrus aurantium, Bai Shao, Licorice, Xiang Shen and Chuan Xiong. If qi stagnation turns into heat over time, with irritability, dry mouth, constipation, red tongue, yellow fur, and stringy pulse, it can be treated with Jia Wei Yi Yao San.