Bleeding in early pregnancy has no effect on the growth and development of the fetus! Vaginal bleeding occurs in about 1/4 of clinical pregnancies. The majority of patients with vaginal bleeding in early pregnancy are bleeding from implantation, which can occur as a result of rupture of blood vessels in the meconium at the site of embryo implantation, mostly from 6 d after fertilization to 29-35 d after the last menstrual period, not always due to abortion factors. However, in early pregnancy, vaginal bleeding in the same amount as menstruation rarely continues, i.e., the pregnancy is aborted due to embryonic death and bleeding from the underlying meconium. What should I do if I bleed? Clinicians usually perform ambulatory blood beta-HCG and progesterone testing in conjunction with abdominal ultrasound in pregnant women with early vaginal bleeding in intrauterine pregnancy for predictive assessment of their pregnancy outcome. Some investigators have reported that serum progesterone levels ≥25 ng/mL (79.25 nmol/L) predict a normal pregnancy, whereas <15 ng/mL (47.55 nmol/L) suggests an adverse pregnancy. The range of variation in blood progesterone levels during pregnancy is relatively limited, with normal pregnancies increasing mildly or remaining unchanged with progesterone levels as gestation progresses, and not decreasing significantly. The time frame for doubling of blood β-HCG levels during early pregnancy in normal pregnancy is 1.5 d and 3 d after 7 weeks of gestation; if its 48-h rise is <66%, ectopic pregnancy and miscarriage are possible. Serum hormone testing is only a monitoring and prediction of pregnancy and can be used to guide clinical management, with ultrasound ultimately determining pregnancy outcome. Vaginal ultrasound can detect the gestational sac at 4-5 weeks of gestation and blood β-HCG level of 1000 mU/mL, while abdominal ultrasound detects the gestational sac about 1 week later than ultrasound and blood β-HCG of 1800-3600 mU/mL. The gestational bud appears at 6 weeks of gestation and the heart tube pulsation appears almost simultaneously with the gestation. The absence of embryonic echogenicity in the gestational sac with a mean diameter of ≥25 mm and the absence of fetal heartbeat in the germline >3 mm suggest miscarriage. Serum hormone testing and ultrasound examination of pregnant mothers can provide valuable information for evaluating the prognosis of pregnancy and can help clinicians to accurately diagnose viable and normal pregnancies and to correctly assess the pregnancy status in a timely manner, which is important for the next step of timely and correct clinical intervention. The warning is that if symptoms of vaginal bleeding occur in early pregnancy, mothers who are prepared for pregnancy need to seek timely medical attention and be alert to the risk of ectopic pregnancy, which can also present with symptoms of vaginal bleeding. If ectopic pregnancy is ruled out, for vaginal bleeding in early pregnancy, you are advised not to worry, get plenty of rest, have a good pregnancy checkup, have a good Down’s syndrome screening after 14 weeks of pregnancy, and have an ultrasound for dysbiosis between 22 and 26 weeks of pregnancy to help you get a healthy and lovely baby.