Abnormal uterine bleeding during puberty should first be examined for the cause of the bleeding, which may be dysfunctional, such as ovulatory disorders, or organic lesions, such as endometrial polyps, adenomyosis, etc., and then be treated with medications and other appropriate treatments according to the disease. 1. Ovulation disorder (1) Hemostasis: sex hormone therapy, commonly used drugs include single progestin therapy, single estrogen preparation, other auxiliary hemostatic drugs (non-steroidal anti-inflammatory drugs, tranexamic acid); curettage (unmarried people with no history of sexual life are not easy to use, and it is only applicable to those who need immediate hemostasis for large amount of bleeding that is ineffective with medication, or those who need to check the endometrial histopathology); adjuvant therapy and so on. (2) Adjustment of menstrual cycle: progesterone or estrogen progesterone sequential method, commonly used drugs for dydrogesterone. 2. Organic lesions (1) Endometrial polyps: small and asymptomatic patients do not need treatment, regular follow-up can be; progesterone and gonadotropin-releasing hormone can reduce the size of the polyp; if necessary, no birth plan for the feasibility of polypectomy. (2) Uterine adenomyosis: It is necessary to combine the patient’s age, symptoms, fertility requirements for individualized selection, commonly used drugs such as danazol, progesterone, etc.; can also be treated by surgery, such as hysterectomy, adenomyosis lesion excision, selective uterine artery embolization, and so on. It is recommended to consult the doctor in time to clarify the cause of the disease, and follow the doctor’s instructions to standardize the use of drugs.