Hemorrhoids applying erythromycin ointment symptoms worsened, may be due to improper use or an adverse reaction to the drug, it is recommended to stop using the medication and local cleaning, if the symptoms do not relieve prompt medical attention. Erythromycin ointment can be used for hemorrhoids combined with local infection ulcers or pus and other conditions of intervention, the drug usually can not immediately relieve pain, itching and other symptoms. The pain may be aggravated if the localized lesion is irritated by too much force during application. Erythromycin ointment may cause signs of local irritation as well as allergic reactions, which may also cause further aggravation of existing pain symptoms. It is recommended to stop the use of the medication immediately after the onset of discomfort and to rinse the area well with water. If the symptoms are not relieved or continue to worsen, it is recommended to go to the hospital in time. Erythromycin Ointment is contraindicated in case of drug allergy, and is prohibited for those who are using chloramphenicol, lincomycin and other drugs, and women during pregnancy are advised to use the drug with caution. Erythromycin ointment is recommended to be used under the guidance of a clinician.