Prozac is composed of fluoxetine, which decreases lower oesophageal sphincter pressure, making gastric emptying delayed and prone to reflux of stomach contents, irritating the oesophageal mucosa and causing a burning sensation in the oesophagus. Patients who have been taking Prozac for a long time should reduce or even discontinue the medication under the guidance of a physician if they experience burning sensation in the oesophagus.