Trigeminal neuralgia is a kind of recurrent paroxysmal pain in the distribution area of the facial trigeminal nerve, sometimes accompanied by other dysfunctions, and its pain nature is like a knife cut, needle prick, electric shock or burning. The pain can be spontaneous or caused by minor stimuli. Common triggers such as washing the face, brushing the teeth, shaving, smiling, etc., usually affect daily life and lead to long-term anxiety, pessimism and disappointment, and some patients even develop suicidal tendencies. The etiology and pathogenesis of primary trigeminal neuralgia are still unclear, and there are more treatment methods for it. C-arm guided radiofrequency thermocoagulation of the trigeminal nerve hemianopia is a better method for patients with trigeminal neuralgia whose conservative treatment is ineffective, and the key to its success lies in accurate puncture and precise positioning. Through a series of scientific and reasonable perioperative care measures such as overall care after admission, psychological support and guidance, active intraoperative cooperation and specialized care, prevention of complications and discharge health education, we ensure the success of the operation, promote the recovery of patients and reduce the occurrence of postoperative complications. The trigeminal nerve is a mixed nerve, including motor nerve and sensory nerve, and the sensory nerve is divided into different nerve fibers, including pain, temperature, touch and pressure nerve fibers, etc. Because the sensitivity of different nerve fibers to temperature is different, it is difficult to damage only the nociceptive nerve while preserving the rest of the nerve when the trigeminal hemianopia is destroyed by radiofrequency thermocoagulation, and there is no more standard radiofrequency thermocoagulation time and There is no more standard RF thermal coagulation time and RF mode, and while destroying the nociceptive sensation in the distribution area of the affected branch of the trigeminal nerve, it is likely to lead to hyperalgesia or loss of tactile sensation in the area. Therefore, after the treatment, it is necessary to prevent food burns, frostbite, stabbing and self-bite to the oral mucosa during the eating process, to protect the oral hygiene, to prevent the normal oral flora from causing disease through the weak oral mucosa, and it is better to rinse the mouth with mouth tide within 1 week after the operation, and not to brush the teeth with toothbrush, which is likely to cause damage and breakage of the gingival mucosa. The patient should also be informed of the causes of hypoesthesia and the precautions to be taken to explain the importance and necessity, so that they can actively cooperate. Closely observe changes in the patient’s consciousness, pupils, eye movements, headache and vital signs. Radiofrequency thermocoagulation of the trigeminal nerve may damage the rest of the cranial nerves, such as the articulating nerve, the talocrural nerve and the sphenoid nerve during the puncture and radiofrequency thermocoagulation treatment, resulting in corresponding nerve damage as well as intracranial hematoma caused by the cavernous sinus and the internal carotid artery adjacent to the medial aspect of the semilunar ganglion. The patient should be placed in the ideal position, and the appropriate position will help the operation to proceed smoothly; the operation should be strictly aseptic, and the eye should be covered with a sterile dressing after the operation; the changes of the patient’s pupil, respiration and other vital signs should be closely observed; the radiofrequency puncture of the trigeminal meningeal ganglion is an imaging-guided puncture, and the patient’s various reactions should be closely observed during the puncture and radiofrequency to ensure intraoperative safety. Once the patient appears to be in respiratory arrest, treatment should be stopped immediately and oxygen should be administered under pressure with a mask. Monitor blood pressure, pulse rate and oxygen saturation until the patient’s condition is stable, and if necessary, tracheal intubation ventilator-assisted ventilation is required. Advise the patient to fast for 8 h and abstain from water for 6 h before surgery to avoid choking and coughing leading to misaspiration and life-threatening events. Patients were instructed to gargle correctly with mouthwash (how to use mouthwash: pour the mouthwash into the lid of the cup, gargle for 3 to 5 min and then spit it out, do not swallow it, and do not gargle with water). The number of gargles per day was unlimited, and each time after eating, gargle with water first, then gargle with mouthwash, and must gargle after meals. Since the patient was absolutely bedridden during the operation, the patient was instructed to practice bed urination and defecation, and the family was informed to prepare a potty for the patient. Most patients with trigeminal neuralgia have a long duration of disease and recurrent pain, which causes great physical and psychological pain to the patients. Therefore, in order to ensure that the surgery can be performed normally, avoid emotional stress and ensure the best mental state, appropriate amount of Valium was given orally as prescribed by the doctor in the evening before surgery. Due to the long duration of the patient’s illness, the patient suffers from long-term pain, physical and mental pain, and often has anxiety and depression, so the patient should be discharged from the hospital with ideological health education, through conversation, listening to music, reading books, newspapers and other ways to divert the patient’s attention from pain, so that they can relax and avoid serious psychological disorders. For patients with corneal reflex, cheek skin and oral mucosa hypersensitivity, they should learn how to protect themselves to prevent accidents such as vision loss and skin mucosa damage. The corneal reflex afferent fibers are the nasociliary nerve from the first branch of the trigeminal nerve. During the process of thermal coagulation of the meniscus, the first branch can be damaged, causing the corneal reflex to diminish or disappear, and paralytic keratitis can lead to thin corneal opacities or even blindness. Therefore, if the corneal reflex is diminished or lost after surgery, Bevosol and levofloxacin eye drops should be given routinely.