Facial myoclonus and Meijer’s syndrome are similar in terms of patient performance, so many patients, including some medical personnel, confuse these two diseases, which affects the treatment. The facial spasm/trigeminal neuralgia treatment center of the Chinese Armed Forces Brain Hospital has seen many such patients and has accumulated some experience in the correct diagnosis of the two diseases. 1, the signs and symptoms of the two diseases are different Both diseases show involuntary frequent blinking, the difference is that facial myospasm is unilateral eye blinking, accompanied by involuntary twitching at the corners of the same side of the mouth, affected by emotions, emotional excitement, and more frequent twitching when communicating with others. In contrast, Meijer’s syndrome shows bilateral eye and mouth lip twitching at the same time, without obvious intervals, and can stop when singing or whistling. 2, the causes of the two diseases are different Facial myoclonus is due to intracranial vascular compression of the facial nerve root, vascular jumping stimulates the facial nerve and causes eye and facial twitching, is congenital carry the onset of acquired, facial nerve root compression is the main cause, is the root of the disease. In contrast, Meijer’s syndrome is a psychological disease, most of the patients with this disease are introverted, withdrawn, love to be more serious and good at drilling, and all the tests are not abnormal. The cause of facial muscle spasm is the compression of the facial nerve root by intracranial blood vessels, resulting in facial and eye twitching, so lifting the compression of the facial nerve is the key to treating the disease. Microvascular decompression is the most effective treatment for facial spasm internationally. The Department of Neurosurgery of the Chinese Armed Forces Brain Hospital has cured more than 1,000 cases of facial spasm using this method, with high cure rate and low recurrence rate. Meijer’s syndrome as a psychological disease its treatment is completely different from facial muscle spasm, the use of surgery is not effective, antipsychotic drugs can improve the symptoms, at the same time to the patient psychological guidance, encourage them to establish confidence to overcome the disease, strengthen physical exercise, more communication with people, more participation in group activities, especially recreational activities, after a period of active comprehensive treatment, most patients can be significantly improved.