Research results show that among the many metal elements, there are a variety of heavy metals that are toxic to human reproduction, and four of the more common heavy metals are lead, mercury, manganese, and cadmium. Lead can act directly on the testes, the core organ of the male reproductive system. Lead can enter the semen through the blood-testis barrier and has a certain accumulation effect. Lead can also indirectly affect male reproductive function by blocking the regulation of the hypothalamic-pituitary-testicular axis, thus affecting the secretion of reproductive hormones, such as causing a significant decrease in testicular copper. Mercury also has an effect on male reproductive function. The more severe mercury poisoning, manifested as a significant decrease in libido and penile erection can not, these symptoms can last for a long time. The effect of manganese on sexual function is mainly manifested as decreased libido, ejaculation disorder, premature ejaculation, impotence, etc. Cadmium mainly accumulates in liver, kidney and testicular tissues. Increased levels of cadmium in testicular tissues can lead to mild fibroplasia in the testes.