Is emotional stress related to infertility? Infertility patients have complex physical and psychological disorders and emotional tensions. Since infertility involves both men and women, there is no doubt that all infertile couples have psychological problems to varying degrees. Different individuals react differently, but all experience more or less mental tension, mostly in the form of depression, loneliness, anger, self-blame and personality defects. Infertility can lead to mental and emotional changes, which in turn can affect conception. If infertile couples do not receive psychological treatment and cannot control their feelings and emotions, a vicious circle of infertility will result.