Women with panda blood need to have antibody potency testing before pregnancy. First, pre-pregnancy preparation: Rh-negative women need to go to a blood center or designated hospital for ABO and Rh blood group identification and to have a pre-pregnancy blood immunology prenatal test (blood group antibody test) before they get pregnant. Women with rare blood types should not abort easily, as abortion may lead to the production of antibodies. Other eugenics tests are no different from those for people with popular blood types, so basically, just do what the maternity hospital requires. (1) If it’s your first pregnancy, you don’t have to be overly nervous. You should have a blood immunology prenatal test (blood group antibody test) from the 5th month of pregnancy, and then have an antibody test at the 7th and 9th month of pregnancy, and then have a repeat antibody test about 6 months after delivery. Anti-D immunoglobulin can be injected within 72 hours after delivery if antibodies are rarely produced during the first pregnancy. Anti-D immunoglobulin is a preventive injection to prevent the production of anti-D antibodies, that is to protect their reproductive rights and future blood transfusion to protect the right to donate blood, so before the production of antibodies to play and not wait until there are antibodies and then consider playing, anti-D antibodies once produced is very difficult to eliminate, prevention is the key. (If antibodies are detected during pregnancy, see the following pregnancy monitoring) (2) If you have a history of miscarriage and childbirth, you need to check your blood type for antibodies starting at 16 weeks, and then have a monthly antibody test (especially after 28 weeks, which is a critical period for antibody production), and then have another antibody check about six months after delivery. If no anti-D antibodies are produced during this period, anti-D immunoglobulin will be injected between 26 and 28 weeks of pregnancy for prophylaxis, and again within 72 hours after delivery. (If antibodies are detected during pregnancy, see the following pregnancy monitoring) (3) It is best to get pregnant when the anti-D potency in Rh-negative women is zero, and if antibodies are already present, they should not exceed 1:8. Mothers-to-be who have given birth to a newborn with hemolytic disease are not suitable to get pregnant immediately when the antibodies in their bodies are still at a high value, as severe intrauterine anemia may occur in the fetus during the middle and late stages of pregnancy, causing fetal edema and stillbirth. In this case, it is necessary to take drugs with antibody immunosuppressant effect beforehand, and if necessary, to carry out plasma exchange or plasma removal treatment to make the antibody potency in the body drop to a low value before conceiving, and the current methods to reduce the antibody, whether it is Chinese medicine or plasma exchange, are not 100% effective, so it is important to prevent antibody production. Second, pregnancy monitoring: (1) regular immunohematological prenatal checkups (blood group antibody testing) for pregnant women: once the presence of antibodies is confirmed, it is important to immediately go to an advanced hospital that has specialized research on rare blood group fertility for treatment. If there are cases where antibodies are found to be produced during pregnancy, it is important to check once every 2 weeks to observe if the antibodies are elevated. If there is an elevation when the antibody potency is greater than 1:16 then it has an effect on the fetus and can be combined with ultrasound to check the fetus for edema, effusion and arterial anemia. When the antibody is elevated above 1:64, amniotic fluid examination can be done: measuring high optical density value at 450nm wavelength, cord vein puncture, fetal blood type, hemoglobin, red blood cell count, bilirubin level and anti-human globulin test. If the antibody potency is >128, plasmapheresis may be performed as appropriate. If the fetus is severely anemic, intrauterine blood transfusion and postpartum blood exchange can be considered. (2) Intrauterine transfusion of fetus. In order to correct severe anemia and save the fetus, intrauterine transfusion of fetus should be combined with early intrauterine transfusion in addition to maternal plasma exchange. All these need to be carried out in an advanced hospital with these hardware facilities and related operational experience, a professional and responsible hospital is quite important. Third, post-delivery treatment: (1) If the mother did not produce Rh antibodies during pregnancy and the fetus is in good condition, it can be treated as a general neonatal routine, but should be closely observed for the possibility of progressive jaundice. (2) If the maternal Rh antibodies are too high, the newborn is often already damaged in the fetal period and can be delivered by early cesarean section. (3) A direct anti-human globulin test of the affected red blood cells should be done after birth to clarify whether the newborn has RhD, RhE or other Rh hemolytic disease, to note the time of appearance of jaundice, the rate of bilirubin elevation and the severity of anemia in the child, and to pay attention to nuclear jaundice caused by high bilirubin. If there is an aggravation of progressive jaundice, neonatal blood exchange should be used, and light and medication should be given at the same time. Improve fetal edema, reduce bilirubin concentration, correct anemia to improve hypoxia and prevent heart failure. If the mother’s prenatal antibodies are known to be high before the pregnancy or before the birth, you should not hesitate to go to a hospital that specializes in maternal plasma exchange, intrauterine transfusion and postpartum neonatal blood exchange for rare blood groups. The blood type of the newborn should be checked early after the delivery of a negative blood type woman and the red blood cell anti-human globulin test should be done to determine whether the newborn has hemolysis, RhD, RhE or other Rh hemolytic diseases.