The first dose is usually started on day 1-5 of the menstrual cycle and every 4 weeks thereafter. The usual course of treatment is 3-6 months, and may be increased or decreased at the discretion of the physician depending on the needs of the condition. Most people may experience irregular bleeding during the first month of dosing, and menorrhagia usually begins in the second month. Possible side effects during dosing usually begin after the second injection and commonly manifest as follows: hot flashes, vaginal dryness, decreased libido, depression, irritability, fatigue, headache, changes in skin structure, and poor sleep. Feedback should be given to the primary care physician in a timely manner, and adjunctive medications may be used to adjust. Adding calcium tablets, increasing aerobic exercise, paying attention to diet and rest are required for more than 2 months of medication. After stopping treatment, ovarian function is restored. For example, in a 3-month course of treatment, ovulation occurs on average 58 days after the last dose, and the first menstruation occurs on average 70-80 days later. If menstruation does not return as scheduled, pregnancy should be excluded first. If there is still no menstruation 4 months after stopping the drug, it is recommended to consult a doctor. Reverse add-on therapy: Excessively low estrogen levels can rapidly cause various symptoms similar to perimenopause, such as hot flashes, irritability, vaginal dryness, and poor sleep, etc. Longer courses of use may even affect bone metabolism and increase bone loss. Therefore, some scholars have proposed the theory and strategy of “reverse addition”, in which small doses of estrogen can be supplemented during GnRHa use without affecting the efficacy of GnRHa and improving symptoms. However, after all, the reverse addition has the effect of partially offsetting the efficacy of GnRHa, so it is better not to use it for a short course of treatment or for mild symptoms. Combined modulation: It refers to the combined use of GnRHa and phytoncide, which neither changes the low estrogen status nor relieves the symptoms of low estrogen. The representative drug is Black Asclepias Extract (trade name: Livermin). Since it works slowly, usually after two to four weeks of continuous use, it is recommended to start using it from the first injection instead of using it when you have symptoms. In addition, Livermin has the disadvantage that it is a self-paying drug and is expensive, costing about 20 yuan per day, so you should use it according to your ability.