Estrogen therapy has been used for more than 60 years since 1932, and more than 40% of perimenopausal women in the United States alone use estrogen replacement drugs. Estrogen replacement therapy can indeed alleviate the symptoms of menopause and improve the atrophy of the female genitourinary tract, prevent bone loss and fractures, enhance memory, prevent cardiovascular disease and diabetes, etc. It is an important treatment to slow down female aging and improve women’s quality of life. With the progress of society and the improvement of women’s quality of life, perimenopausal estrogen replacement therapy has attracted a great deal of attention from women. In order to make people understand ERT correctly, narrow the gap between ERT and scientific evidence, and change the incorrect views and information-induced fears of applying estrogen replacement therapy, the answers are as follows: What kind of cases are necessary for hormone replacement therapy? A: The following three conditions are considered at home and abroad, namely: (1) menopausal syndromes such as hot flashes, night sweats and poor mood; (2) a series of symptoms caused by atrophy of the genitourinary system, such as urinary urgency, urinary frequency (many people mistakenly think they have urinary tract infections), urinary incontinence (mildly effective), painful intercourse, difficulty in intercourse and atrophic vaginitis; (3) prevention of osteoporosis. What are the contraindications to hormone replacement therapy? A: Those who have recently suffered from myocardial infarction, cerebrovascular lesions, acute or recurrent thrombotic lesions, those who have suffered from endometrial cancer, breast cancer, unexplained vaginal bleeding, and those with high risk factors such as breast cancer in the immediate family should be contraindicated. In addition, patients with hypertension, diabetes, hyperlipidemia, and uterine fibroids must also be cautious when taking estrogen.