Treatment of pancreatitis

  The treatment of pancreatitis is based on clinical manifestations and typing, and appropriate treatment methods are selected.  1, non-surgical treatment The initial stage of acute pancreatitis, light pancreatitis and those who are not yet infected should be treated non-surgically.  (1) Fasting, nasogastric tube decompression: continuous gastrointestinal decompression to prevent vomiting and aspiration. The administration of full gastrointestinal motility drugs can reduce abdominal distension.  (2) Replenish body fluids and prevent shock: All patients should receive intravenous fluid, electrolytes and calories to maintain circulatory stability and water-electrolyte balance. Prevent hypotension, improve microcirculation, and ensure pancreatic perfusion is beneficial to the treatment of acute pancreatitis.  (3) Antispasmodic and analgesic: If the diagnosis is clear. Early in the course of the disease, analgesics (pethidine) can be given symptomatically. However, it is appropriate to give antispasmodics (scopolamine, atropine) at the same time. Morphine is prohibited to avoid causing spasm of the sphincter of Oddi.  (4) Inhibition of pancreatic exocrine secretion and pancreatic enzyme inhibitors: gastric tube decompression, H2 receptor blockers {such as cimetidine), anticholinergics (such as scopolamine, atropine), growth inhibitors, etc., but the latter are expensive and are generally used in patients with more severe disease. Trypsin inhibitors such as peptidase, gabex, etc. have -certain inhibition of the role of trypsin.  (5) Nutritional support: early fasting. It mainly relies on complete parenteral nutrition (TPN). When abdominal pain, pressure pain and intestinal obstruction symptoms are reduced, diet can be resumed. Except for hyperlipidemic patients, fat emulsion can be applied as a heat source.  (6) Application of antibiotics: Early antibiotic treatment is given. In severe pancreatitis combined with pancreatic or peripancreatic necrosis, broad-spectrum antibiotics applied intravenously or selective transintestinal application of antibiotics can prevent bacterial infection and fungal infection caused by intestinal flora displacement.  (7) Chinese herbal medicine treatment: Under the condition that vomiting is basically controlled. Inject herbal medicine through gastric tube and clamp the tube for 2 hours after injection. Commonly used as compound Qing Pancreatic Tang with addition and reduction: Yinhua, Lianjia, Huanglian, Scutellaria, Houpao, Citrus aurantium, Mu Xiang, Safflower and raw rhubarb (later down). Raw rhubarb 15g can also be used alone for intragastric tube instillation. 2 times a day.  (8) Treatment of abdominal exudate: The abdominal exudate of acute pancreatitis contains a variety of harmful substances that can cause hypotension, respiratory failure, liver failure and changes in vascular permeability. In severe pancreatitis, it is generally believed that abdominal exudate can be absorbed on its own. If the abdominal distension is obvious, abdominal lavage should be done if there is much peritoneal exudate.  2, surgical treatment (1) surgical treatment of secondary pancreatic infection: there are two main surgical methods: ① dissection to remove necrotic tissue and placement of multiple porous drains for continuous postoperative lavage. The incision is then sutured.  (ii) Dissection to remove necrotic tissue and partial open drainage of the incision. The transabdominal route is easy to reveal, and the transverse epigastric incision is particularly easy to reveal and manipulate intraoperatively. The thick pus and infected necrotic tissues filled with tissue debris are removed intraoperatively, and regular pancreatic resection is not performed, avoiding dissection with sharp instruments to prevent pancreatic duct injury. The peripancreatic area is freed and loosened and flushed, and regional drainage should be adequate with multiple drainage tubes placed for postoperative irrigation. The trauma is partially open to drainage, which, in addition to adequate drainage, also facilitates the removal of continued necrotic pancreatic tissue several times postoperatively. Gastrostomy, jejunostomy (for enteral nutritional support) and biliary drainage can be performed simultaneously in water. Occasionally, a single abscess or infected pancreatic pseudocyst can be treated with percutaneous puncture and drainage.  (2) Management of cholestatic pancreatitis: In severe cholestatic pancreatitis. In cases with embedded stones in the jugular abdomen, combined with biliary obstruction or biliary infection, emergency surgery or early surgery (within 72 hours) should be performed to remove biliary obstruction, remove stones, unblock drainage, and choose cholecystectomy or small omental pancreatic drainage according to the condition. If available, the stone can be removed via fiberoptic duodenoscopic Oddi sphincterotomy, which is highly effective and has few complications. If the patient does not have biliary obstruction or infection, non-surgical supportive treatment should be performed, and elective biliary surgery should be performed before discharge when the disease is in remission to avoid recurrence after discharge. Some patients may drain the stone on their own during hospitalization and do not need further surgery. Alternatively, patients may be admitted for biliary surgery 2-4 weeks after the acute pancreatitis is cured.  In severe biliary pancreatitis with embedded stones in the jugular abdomen, combined with biliary obstruction or biliary infection, emergency surgery or early surgery (within 72 hours) should be performed to relieve biliary obstruction, remove stones, unblock drainage, and choose to perform cholecystectomy or small omental pancreatic drainage according to the condition. If available, the stone can be removed via fiberoptic duodenoscopic Oddi sphincterotomy, which is highly effective and has few complications. If the patient does not have biliary obstruction or infection, non-surgical supportive treatment should be performed, and elective biliary surgery should be performed before discharge when the disease is in remission to avoid recurrence after discharge. Some patients may drain the stone on their own during hospitalization and do not need further surgery. Alternatively, patients may be admitted for biliary surgery 2-4 weeks after the acute pancreatitis is cured.