The treatment of chronic pancreatitis is mainly to remove the cause, control the symptoms, and improve the function of pancreas; it is usually difficult to cure completely, but only to control the symptoms, including general treatment, internal medicine treatment, endoscopic treatment, while surgical treatment may be the method of complete treatment. 1. General treatment: patients should abstain from alcohol and smoking, avoid excessive high-fat and high-protein diet, and exercise appropriately. 2. Internal medicine treatment: the main purpose is to inhibit the secretion of pancreatic enzymes during the acute exacerbation period, and the commonly used medications are pancreatic enzyme preparations, antioxidants and growth inhibitors, and the commonly used medications are betahistine mesylate, octreotide, etc. For the treatment of pancreatic exocrine insufficiency, the main purpose is to apply exogenous pancreatic enzyme replacement therapy, and the commonly used medications are high-activity lipase, omeprazole and so on. 3. Endoscopic treatment: the main indications are pancreatic duct stone, pancreatic duct stenosis, pancreatic pseudocyst, bile duct stenosis, etc. It is helpful for relieving pancreatic pain and improving patients’ quality of life. 4. Surgical treatment: mainly used for intractable pain that cannot be relieved by conservative treatment or endoscopic treatment, those who are not suitable for internal medicine and interventional therapy, and those who are suspected of malignant changes, the main surgical modalities are pancreatic resection, pancreatic drainage and combined surgery. Pancreatic resection can completely treat chronic pancreatitis, but there are postoperative complications, such as pancreatic hyperglycemia and so on. Patients with chronic pancreatitis are advised to actively seek medical attention for standardized treatment, not to self-medicate, and to follow up regularly.