”Passenger suddenly fainted after 10 hours of flying”, similar news is common on the internet. What is happening behind this? Hospitalization, surgery and sedentary lifestyle all contribute to the incidence of venous thrombosis, but too few people are aware of the deadly consequences of blood clots in the legs and lungs, a preventable condition from which many people die. October 13, 2017, is the fourth World Thrombosis Day worldwide. Let’s get ahead of the game with thrombosis prevention and control! Blood flowing in the veins is like water flowing in a river. The river has sediment, the blood has blood cells; the river has a dam to intercept, the blood also has a valve to control the switch. If the river channel has sediment all over and collects into a mass, then the water in the river will look around for a breach and flood. If the blood has clotting conditions such as more blood lipids and more clotting factors, then blood cells will build up and gather to a certain point to form clots. ”Thrombosis is the common pathogenesis of the top three fatal cardiovascular diseases worldwide – myocardial infarction, stroke and venous thromboembolism. The severity of the first two is widely understood by the public, and while venous thromboembolism ranks as the third leading cardiovascular killer, public awareness is unfortunately low.” Venous thromboembolism includes deep vein thrombosis, in which a blood clot forms in the deep veins of the legs, and pulmonary embolism, in which a blood clot reaches the lungs with blood flow and blocks a blood vessel, belonging to different periods of one disease. The most serious consequence of deep vein thrombosis is the occurrence of pulmonary embolism. The most serious consequence of DVT is pulmonary embolism. Once it occurs, it is often so dangerous that clinicians have little time to resuscitate the patient, and death can occur within 1-2 hours in severe cases, and the risk of recurrence of fatal pulmonary embolism remains in patients after the risk period. According to the International Society of Thrombosis and Haemostasis, 100,000-300,000 people die from venous thrombosis in the United States each year, with more than 500,000 related hospitalizations. In Europe, 500,000 people die from venous thrombosis each year, more than AIDS, breast and prostate cancer, and highway traffic accidents combined. In China, the venous thrombosis situation is equally dire, but the lack of epidemiological data masks the widespread impact of thrombotic disease. Sitting for an hour increases the risk of thrombosis by 10% Deep vein thrombosis and pulmonary embolism can occur in anyone at any age and is not “exclusive” to the elderly. Data show that for every hour of sitting still, the risk of deep vein thrombosis increases by 10%; sitting for more than 90 minutes reduces blood circulation to the knee by 50%. This is due to the pathogenesis of venous thrombosis, which includes venous endothelial damage, hypercoagulable blood and stagnant venous blood flow. For example, hospitalization, surgery and sedentary lifestyle increase the incidence of venous thrombosis; moreover, with the improvement of people’s living standard, diet and lifestyle changes in recent years, the incidence of venous thromboembolism patients worldwide is also increasing year by year. For the harm of thrombosis, in addition to the acute stage leading to life-threatening, most of the patients gradually appear pain, swelling, edema and skin pigmentation of the limbs after activity within 1-2 years after the formation of venous thrombosis, and this ratio can be as high as 50%, among which 5-10% of patients eventually develop venous ulcers, which seriously affects the quality of life, and this phenomenon is called post-thrombotic syndrome, and this sequelae appears This phenomenon is called post-thrombotic syndrome, which is mainly caused by the obstruction of venous blood flow and increased pressure after the formation of deep vein thrombosis in the lower extremities. For most people, however, venous thrombosis can be prevented. “Active participation in sports and exercise will effectively reduce the risk of blood clots. If you are braking for long periods of time, such as driving or flying on a long trip, or even sitting at a desk for long periods of time, especially with your knees bent, it is recommended to take a moment to stand up, stretch your legs, and walk around the neighborhood, which is important for healthy circulation. It is important for hospitals to establish and implement preventive monitoring and treatment for high-risk patients.” Anticoagulation at the heart of venous thromboembolism treatment What is the treatment if a venous thromboembolism unfortunately occurs? Early medical attention is the key to treating venous thromboembolism, preventing sudden death, and reducing the sequelae of thrombosis, and a combination of anticoagulation, thrombolysis, and thrombolysis can significantly reduce the mortality rate and improve the efficacy of thromboembolic disease. ”Current national and international clinical guidelines point to anticoagulation as a cornerstone in the prevention and treatment of thrombotic disease with potentially fatal risks. Traditional anticoagulants vary greatly in individual dosing, require frequent monitoring, are slow to take effect, and have food-drug interactions, making their use inconvenient. Currently, new oral anticoagulants such as rivaroxaban overcome the limitations of traditional anticoagulants with oral administration, rapid onset of action, predictable anticoagulation, no need for routine coagulation monitoring or frequent dose adjustments, low risk of drug-drug interactions, fewer food-drug interactions, prevention of the risk of recurrent deep vein thrombosis and pulmonary embolism, and their stability and durability are of great importance for a good patient recovery. ” Anticoagulation therapy can effectively prevent the recurrence of thrombosis and is the core of treatment throughout the treatment; thrombolytic therapy and minimally invasive thrombolytic therapy in the acute phase can effectively remove thrombus, and selective implantation of filters can effectively prevent lethal pulmonary embolism; interventional therapy, pressure therapy, drug therapy and rehabilitation therapy in the chronic phase can relieve venous hypertension in the lower extremities. The occurrence of thromboembolic disease as soon as possible to the vascular surgery, according to the condition of the comprehensive use of the above-mentioned treatment tools, in order to achieve the whole scientific management of thromboembolic disease, so that patients with venous thromboembolism no longer suffer from the disease.