With the widespread use of the targeted drug tyrosine kinase inhibitors (hereinafter referred to as TKI), the survival of slow-grain patients taking TKI drugs is close to that of their healthy peers, and their quality of life is significantly improved, of which the integrity of the family is a non-negligible part. Many young patients with LRD are faced with the question: “Can I take TKI drugs and still have a healthy child? Here we will answer the question of fertility while taking the medication. Male patients can become fathers normally While taking TKI drugs, very few men will have reduced sperm count and activity, but their fertility will not decrease. Adult male patients with TKI can have children normally, and the rate of fetal malformations is not increased compared to the general population. Male patients taking TKI do not need to discontinue the drug for fertility needs. If patients are concerned that the decrease in sperm count after taking the drug will affect conception, they can freeze their sperm before taking the drug to prepare for future fertility. Female patients What if I get pregnant while taking the medication? Relatively speaking, female patients have a lot more restrictions on fertility. First, doctors may recommend contraception for female patients taking TKI drugs. This is because surveys have shown that taking TKI drugs during pregnancy can increase the risk of miscarriage and the occurrence of fetal malformations, with the probability of a malformed fetus approaching 10%, significantly higher than normal. The risk of taking TKI drugs is especially high in the first trimester of pregnancy. The toxicity of TKI drugs to the fetus should be taken into account when pregnancy occurs while taking the drugs. If you are already taking the drug when you find out you are pregnant, you need to weigh the effect of the drug on the fetus and the effect of stopping the drug on the mother’s disease, and consult an experienced physician before deciding whether the fetus should stay or go. Patients who have normal childbirth need to start taking the medication as soon as possible and avoid breastfeeding. This is because the medication can enter the breast milk and affect the fetus.