Chest tightness at night can be seen in normal people, but also may be caused by heart disease, bronchial asthma, vegetative nerve disorders and other diseases, the patient should consult a doctor in a timely manner, to clarify the cause of the disease. 1. Physiological conditions: anger, poor sleep quality, etc. can be caused by sleep at night, chest tightness can not sleep, such people should keep in a happy mood, do appropriate physical exercise, generally without special. 2. Heart disease: coronary heart disease, heart failure, hypertension, etc. can cause chest tightness at night, mostly in the middle-aged and elderly people, the patient will also have chest pressure and other symptoms, should consult a doctor in a timely manner, under the guidance of the doctor to carry out the appropriate treatment. 3. Bronchial asthma: if there is a history of allergies in young people at night sleep chest tightness can not sleep, and its recent contact with pollen, animal fur and other substances, should be considered to be caused by asthma, can be nebulized inhalation of albuterol, dexamethasone and so on. 4. Vegetative nerve disorders: long-term mental stress caused by fainting, blood pressure abnormalities, chest tightness at night, can not sleep through the air, such people should maintain a happy mood, when necessary, the use of glutathione, propranolol and other treatment. All of the above drugs should be used under the guidance of a doctor.