Pathology followed by immunohistochemistry is not serious. Immunohistochemistry is to identify antigens in tissues and cells through chemical reactions and to locate, characterize and quantify them, which can be used for differential diagnosis of malignant tumors. It can also determine the primary site and pathological classification of malignant tumors, and can also provide a basis for patients to develop a targeted treatment plan. Currently commonly used immunohistochemical methods include immunofluorescence, immunoenzymatic labeling, affinity histochemistry and so on. When a morphological diagnosis cannot be clearly made in the routine pathologic diagnosis of a tumor, immunohistochemistry is generally recommended for further differential diagnosis of the disease. It is not directly related to the severity of the disease and does not mean that the disease is serious. Some diseases may need immunohistochemical staining to determine the patient’s prognosis. Therefore, immunohistochemistry after pathology is not necessarily serious. It is recommended to follow the doctor’s instructions and actively cooperate with the examination.