Pain in the perineal area of men accompanied by hematuria may be urolithiasis, urinary tract infection, urinary tract tumor, trauma or others. 1. Urolithiasis: typical symptoms are pain accompanied by hematuria, which may be accompanied by nausea and vomiting, urinary frequency and urgency, urinary pain and other symptoms. 2. Urinary tract infection: typical symptoms include frequent urination and painful urination, partly accompanied by hematuria, with or without fever. 3. Urological tumor: typical symptoms are painless hematuria throughout the whole process, preferably occurring in middle-aged and old people. 4. Urinary tract trauma: there is a history of trauma, hematuria can occur after urinary tract injury, it should be noted that there is no obvious correlation between the degree of hematuria and the severity of the disease. 5. Others: such as acute and chronic nephritis, nephrotic syndrome, IgA nephropathy, systemic lupus erythematosus, sepsis and so on. Although activity-related pain and hematuria are typical symptoms of urinary tract stones, any patient presenting with hematuria should be carefully examined and the cause identified, especially in adults, to rule out the possibility of malignancy.