Early surgical treatment of diabetic peripheral neuropathy may be effective, while surgery in the middle and late stages is risky and less effective than in the early stages. If diabetic patients do not have effective control of their blood glucose for a long time, the high blood glucose state will easily lead to diabetic peripheral neuropathy, which is a serious chronic complication. Prolonged hyperglycemia can lead to peripheral neuropathy, which affects the sensory and conduction functions of nerves. In the early stage of diabetic peripheral neuropathy, nerve decompression surgery can be performed to avoid excessive edema and compression of the nerves, which is expected to restore the function of the nerves. However, once the disease reaches the middle or late stage, the nerve has been irreversibly damaged, even if the surgical treatment, it is difficult to restore the function of the nerve. Moreover, for diabetic patients, high blood sugar state is prone to secondary infection, wound non-healing and other risks, at this time the risk of surgery will also greatly increase. Therefore, once diabetic peripheral neuropathy occurs, it is necessary to consult a doctor in time and follow the doctor’s instructions for timely treatment to avoid aggravation of the condition.