Cough, chest tightness and shortness of breath after lobectomy are considered to be caused by lung infection, decreased lung function and metastasis of lung cancer, etc. At present, medication, oxygen therapy and radiotherapy can be taken to alleviate the symptoms. 1. Lung infection: after lobectomy, if patients stay in bed for a long time, it is easy to lead to lung infection and inflammation. Reasonable use of antibiotics, including cefixime, ceftriaxone sodium, etc., according to the type of causative organism is needed as soon as possible, and then oral ribavirin if it is caused by viral infection. Oxygen therapy is needed if necessary. If cough, sputum, then oral dextromethorphan; sputum can not be discharged, oral aminoglutethimide hydrochloride. 2. Decrease in lung function: After lobectomy, patients’ immunity will decrease, which will easily lead to decrease in lung function, thus causing cough, chest tightness and shortness of breath, oxygen should be inhaled as soon as possible to ensure sufficient oxygen. When coughing, then take dextromethorphan orally. 3. Lung cancer metastasis: when cancer cells metastasize to lung tissues, causing cough and chest tightness, local radiotherapy should be carried out as soon as possible, which can inhibit the cancer cells, reduce the size of the mass and alleviate the symptoms. Cough, chest tightness and shortness of breath after lobectomy may also be caused by cardiac insufficiency. At present, regular review should be conducted to clarify the cause of the disease and then follow the doctor’s instruction for targeted treatment.